4-Methylenesterols from a sponge Theonella swinhoei

Jheng-Kun Guo; Ching-Ying Chiang; Mei-Chin Lu; Wen-Been Chang; Jui-Hsin Su

doi:10.3390/md10071536

4-Methylenesterols from a sponge Theonella swinhoei

Mar Drugs. 2012 Jul;10(7):1536-1544. doi: 10.3390/md10071536. Epub 2012 Jul 19.

Authors

Jheng-Kun Guo^{1

2}, Ching-Ying Chiang³, Mei-Chin Lu^{1

4}, Wen-Been Chang^{1

2}, Jui-Hsin Su^{1

4

5}

Affiliations

¹ National Museum of Marine Biology & Aquarium, Pingtung 944, Taiwan.
² Graduate Institute of Marine Biodiversity and Evolutionary Biology, National Dong Hwa University, Pingtung 944, Taiwan.
³ Center of General Studies, National Kaohsiung Marine University, Kaohsiung 811, Taiwan.
⁴ Graduate Institute of Marine Biotechnology, National Dong Hwa University, Pingtung 944, Taiwan.
⁵ Asia-Pacific Ocean Research Center, National Sun Yat-sen University, Kaohsiung 804, Taiwan.

Abstract

Three new 4-methylenesterols, theonellasterol K (1), acetyltheonellasterol (2) and acetyldehydroconicasterol (3), along with two known sterols, theonellasterol (4) and theonellasterone (5), were isolated from the sponge Theonella swinhoei. The structures of these compounds were elucidated on the basis of their spectroscopic data and comparison of the NMR data with those of known analogues. Compound 1 exhibited significant cytotoxic activity against HCT-116, K562 and Molt 4 cancer cell lines.

Keywords: 4-methylenesterols; Theonella; sponge.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Antineoplastic Agents / pharmacology
HCT116 Cells
Humans
K562 Cells
Magnetic Resonance Spectroscopy
Sterols / chemistry
Sterols / isolation & purification*
Sterols / pharmacology
Theonella / chemistry*

Substances

Antineoplastic Agents
Sterols