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Selective PROTAC-mediated degradation of SMARCA2 is efficacious in SMARCA4 mutant cancers.
Nat Commun. 2022 Nov 10;13(1):6814. doi: 10.1038/s41467-022-34562-5.
Nat Commun. 2022.
PMID: 36357397
Free PMC article.
PROTACs Targeting BRM (SMARCA2) Afford Selective In Vivo Degradation over BRG1 (SMARCA4) and Are Active in BRG1 Mutant Xenograft Tumor Models.
Berlin M, Cantley J, Bookbinder M, Bortolon E, Broccatelli F, Cadelina G, Chan EW, Chen H, Chen X, Cheng Y, Cheung TK, Davenport K, DiNicola D, Gordon D, Hamman BD, Harbin A, Haskell R, He M, Hole AJ, Januario T, Kerry PS, Koenig SG, Li L, Merchant M, Pérez-Dorado I, Pizzano J, Quinn C, Rose CM, Rousseau E, Soto L, Staben LR, Sun H, Tian Q, Wang J, Wang W, Ye CS, Ye X, Zhang P, Zhou Y, Yauch R, Dragovich PS.
Berlin M, et al. Among authors: pizzano j.
J Med Chem. 2024 Jan 25;67(2):1262-1313. doi: 10.1021/acs.jmedchem.3c01781. Epub 2024 Jan 5.
J Med Chem. 2024.
PMID: 38180485
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Development of Liposome Systems for Enhancing the PK Properties of Bivalent PROTACs.
Kou P, Levy ES, Nguyen AD, Zhang D, Chen S, Cui Y, Zhang X, Broccatelli F, Pizzano J, Cantley J, Bortolon E, Rousseau E, Berlin M, Dragovich P, Sethuraman V.
Kou P, et al. Among authors: pizzano j.
Pharmaceutics. 2023 Aug 8;15(8):2098. doi: 10.3390/pharmaceutics15082098.
Pharmaceutics. 2023.
PMID: 37631312
Free PMC article.
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Role of regional absorption and gastrointestinal motility on variability in oral absorption of a model drug.
Narang AS, Balakrishnan A, Morrison J, Li J, Wang J, Gu H, Taylor K, Santone K, Ehrmann J, Beyer S, Lu X, Ketner R, Pizzano J, Orcutt T, Shields E, Dulac H, Aborn S, Batchelder M, Lentz K.
Narang AS, et al. Among authors: pizzano j.
Eur J Pharm Biopharm. 2017 Aug;117:333-345. doi: 10.1016/j.ejpb.2017.04.026. Epub 2017 Apr 25.
Eur J Pharm Biopharm. 2017.
PMID: 28455207
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Evaluation of cynomolgus monkey pregnane X receptor, primary hepatocyte, and in vivo pharmacokinetic changes in predicting human CYP3A4 induction.
Kim S, Dinchuk JE, Anthony MN, Orcutt T, Zoeckler ME, Sauer MB, Mosure KW, Vuppugalla R, Grace JE Jr, Simmermacher J, Dulac HA, Pizzano J, Sinz M.
Kim S, et al. Among authors: pizzano j.
Drug Metab Dispos. 2010 Jan;38(1):16-24. doi: 10.1124/dmd.109.029637.
Drug Metab Dispos. 2010.
PMID: 19833845
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Quantitative relationship between rifampicin exposure and induction of Cyp3a11 in SXR humanized mice: extrapolation to human CYP3A4 induction potential.
Kim S, Pray D, Zheng M, Morgan DG, Pizzano JG, Zoeckler ME, Chimalakonda A, Sinz MW.
Kim S, et al. Among authors: pizzano jg.
Drug Metab Lett. 2008 Aug;2(3):169-75. doi: 10.2174/187231208785425809.
Drug Metab Lett. 2008.
PMID: 19356089
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