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Freeze-dried nanocrystal dispersion of novel deuterated pyrazoloquinolinone ligand (DK-I-56-1): Process parameters and lyoprotectant selection through the stability study.
Mitrović JR, Bjelošević Žiberna M, Vukadinović A, Knutson DE, Sharmin D, Kremenović A, Ahlin Grabnar P, Planinšek O, Lunter D, Cook JM, Savić MM, Savić SD. Mitrović JR, et al. Eur J Pharm Sci. 2023 Oct 1;189:106557. doi: 10.1016/j.ejps.2023.106557. Epub 2023 Aug 6. Eur J Pharm Sci. 2023. PMID: 37544333 Free article.
The Impact of the Oil Phase Selection on Physicochemical Properties, Long-Term Stability, In Vitro Performance and Injectability of Curcumin-Loaded PEGylated Nanoemulsions.
Đoković JB, Demisli S, Savić SM, Marković BD, Cekić ND, Randjelovic DV, Mitrović JR, Lunter DJ, Papadimitriou V, Xenakis A, Savić SD. Đoković JB, et al. Among authors: mitrovic jr. Pharmaceutics. 2022 Aug 10;14(8):1666. doi: 10.3390/pharmaceutics14081666. Pharmaceutics. 2022. PMID: 36015291 Free PMC article.
High amount of lecithin facilitates oral delivery of a poorly soluble pyrazoloquinolinone ligand formulated in lipid nanoparticles: Physicochemical, structural and pharmacokinetic performances.
Mitrović JR, Divović-Matović B, Knutson DE, Petković M, Djorović D, Randjelović DV, Dobričić VD, Đoković JB, Lunter DJ, Cook JM, Savić MM, Savić SD. Mitrović JR, et al. Int J Pharm. 2023 Feb 25;633:122613. doi: 10.1016/j.ijpharm.2023.122613. Epub 2023 Jan 16. Int J Pharm. 2023. PMID: 36657554 Free PMC article.
Curcumin Loaded PEGylated Nanoemulsions Designed for Maintained Antioxidant Effects and Improved Bioavailability: A Pilot Study on Rats.
Đoković JB, Savić SM, Mitrović JR, Nikolic I, Marković BD, Randjelović DV, Antic-Stankovic J, Božić D, Cekić ND, Stevanović V, Batinić B, Aranđelović J, Savić MM, Savić SD. Đoković JB, et al. Among authors: mitrovic jr. Int J Mol Sci. 2021 Jul 27;22(15):7991. doi: 10.3390/ijms22157991. Int J Mol Sci. 2021. PMID: 34360758 Free PMC article.
New Imidazodiazepine Analogue, 5-(8-Bromo-6-(pyridin-2-yl)-4H-benzo[f]imidazo[1,5-a][1,4]diazepin-3-yl)oxazole, Provides a Simplified Synthetic Scheme, High Oral Plasma and Brain Exposures, and Produces Antiseizure Efficacy in Mice, and Antiepileptogenic Activity in Neural Networks in Brain Slices from a Patient with Mesial Temporal Lobe Epilepsy.
Sharmin D, Divović B, Ping X, Cerne R, Smith JL, Rezvanian S, Mondal P, Meyer MJ, Kiley ME, Arnold LA, Mian MY, Pandey KP, Jin X, Mitrović JR, Djorović D, Lippa A, Cook JM, Golani LK, Scholze P, Savić MM, Witkin JM. Sharmin D, et al. Among authors: mitrovic jr. ACS Chem Neurosci. 2024 Feb 7;15(3):517-526. doi: 10.1021/acschemneuro.3c00555. Epub 2024 Jan 4. ACS Chem Neurosci. 2024. PMID: 38175916
Nanocrystal dispersion of DK-I-56-1, a poorly soluble pyrazoloquinolinone positive modulator of α6 GABAA receptors: Formulation approach toward improved in vivo performance.
Mitrović JR, Divović B, Knutson DE, Đoković JB, Vulić PJ, Randjelović DV, Dobričić VD, Čalija BR, Cook JM, Savić MM, Savić SD. Mitrović JR, et al. Eur J Pharm Sci. 2020 Sep 1;152:105432. doi: 10.1016/j.ejps.2020.105432. Epub 2020 Jun 18. Eur J Pharm Sci. 2020. PMID: 32565331 Free PMC article.