Chemical and photochemical synthesis of substituted dihydro-thieno[2',3':4,5]thieno[2,3-c]quinolin-6-ones and tetrahydro-dithieno[2,3-b:2',3'-d]thieno[2'',3''c:2'',3''c']diquinolin-6,14-dione

Jelena Blazević Safarik; Jasna Dogan Koruznjak; Grace Karminski-Zamola

doi:10.3390/10010279

Chemical and photochemical synthesis of substituted dihydro-thieno[2',3':4,5]thieno[2,3-c]quinolin-6-ones and tetrahydro-dithieno[2,3-b:2',3'-d]thieno[2'',3''c:2'',3''c']diquinolin-6,14-dione

Molecules. 2005 Jan 31;10(1):279-88. doi: 10.3390/10010279.

Authors

Jelena Blazević Safarik¹, Jasna Dogan Koruznjak, Grace Karminski-Zamola

Affiliation

¹ Department of Organic Chemistry, Faculty of Chemical Engineering and Technology, University of Zagreb, Marulićev trg 20, 10000 Zagreb, Croatia.

Abstract

Some new substituted dihydrothieno[2',3':4,5]thieno[2,3-c]quinolin-6-ones 9- 12 and tetrahydrodithieno[2,3-b: 2',3'-d]thieno[2'',3''-c:2'',3''-c']diquinolin-6,14-dione (17) were prepared from the corresponding new anilides 5-8 and from the corresponding dianilide 15, respectively, by a multistep combination of chemical and photochemical reactions. All the prepared compounds are of particular interest because they might serve as DNA intercalators in anticancer therapy.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Anilides / chemistry*
Antineoplastic Agents / chemical synthesis*
Antineoplastic Agents / chemistry
Chemistry, Organic
Cyclization
Heterocyclic Compounds / chemical synthesis*
Heterocyclic Compounds / chemistry
Models, Biological
Organic Chemistry Phenomena
Photochemistry
Quinolones / chemical synthesis*
Thiophenes / chemical synthesis*
Thiophenes / chemistry

Substances

Anilides
Antineoplastic Agents
Heterocyclic Compounds
Quinolones
Thiophenes
tetrahydrodithieno(2,3-b-2',3'-d)thieno(2'',3''c-2'',3''c')diquinolin-6,14-dione