Retrograde movements determine effective stem cell numbers in the intestine.
Azkanaz M, Corominas-Murtra B, Ellenbroek SIJ, Bruens L, Webb AT, Laskaris D, Oost KC, Lafirenze SJA, Annusver K, Messal HA, Iqbal S, Flanagan DJ, Huels DJ, Rojas-Rodríguez F, Vizoso M, Kasper M, Sansom OJ, Snippert HJ, Liberali P, Simons BD, Katajisto P, Hannezo E, van Rheenen J.
Azkanaz M, et al.
Nature. 2022 Jul;607(7919):548-554. doi: 10.1038/s41586-022-04962-0. Epub 2022 Jul 13.
Nature. 2022.
PMID: 35831497
Free PMC article.
Here we show using intravital microscopy that, despite similarities in the number and distribution of proliferative cells with an Lgr5 signature in mice, small intestinal crypts contain twice as many effective stem cells as large intestinal crypts. We find that, although passivel …
Here we show using intravital microscopy that, despite similarities in the number and distribution of proliferative cells with an Lgr5 signa …