Abstract
Using gel chromatography two different 99mTc-PPi complexes (complex I and II) were observed under various pH-values. In neutral medium complex II was the main product while in acidic or alkaline media complexes I and II were formed. Our results related to the organ distribution in mice revealed that complex II is a bone-seeking agent whereas complex I concentrates in the kidneys.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Animals
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Bone and Bones / diagnostic imaging
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Chromatography, Gel
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Diphosphates* / metabolism
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Hydrogen-Ion Concentration
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Kidney / diagnostic imaging
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Mice
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Rabbits
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Radionuclide Imaging
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Technetium Tc 99m Pyrophosphate
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Technetium* / metabolism
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Tissue Distribution
Substances
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Diphosphates
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Technetium Tc 99m Pyrophosphate
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Technetium