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Showing results for jason philtrum
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Formation and closure of macropinocytic cups in Dictyostelium.
Lutton JE, Coker HLE, Paschke P, Munn CJ, King JS, Bretschneider T, Kay RR. Lutton JE, et al. Curr Biol. 2023 Aug 7;33(15):3083-3096.e6. doi: 10.1016/j.cub.2023.06.017. Epub 2023 Jun 27. Curr Biol. 2023. PMID: 37379843 Free PMC article.
We use light-sheet microscopy to define an underlying set of principles by which macropinocytic cups are shaped and closed in Dictyostelium amoebae. Cups form around domains of PIP3 stretching almost to their lip and are supported by a specialized F-actin scaffold from …
We use light-sheet microscopy to define an underlying set of principles by which macropinocytic cups are shaped and closed in Dictyostelium …
Syndromes of the first and second branchial arches, part 2: syndromes.
Johnson JM, Moonis G, Green GE, Carmody R, Burbank HN. Johnson JM, et al. AJNR Am J Neuroradiol. 2011 Feb;32(2):230-7. doi: 10.3174/ajnr.A2073. Epub 2010 Apr 1. AJNR Am J Neuroradiol. 2011. PMID: 20360348 Free PMC article. Review.
The radiologic evaluation of syndromes of the first and second BA should begin first by studying a series of isolated defects (cleft lip with or without CP, micrognathia, and EAC atresia) that compose the major features of these syndromes and allow a more specific diagnosi …
The radiologic evaluation of syndromes of the first and second BA should begin first by studying a series of isolated defects (cleft lip …
Fragment Optimization of Reversible Binding to the Switch II Pocket on KRAS Leads to a Potent, In Vivo Active KRASG12C Inhibitor.
Bröker J, Waterson AG, Smethurst C, Kessler D, Böttcher J, Mayer M, Gmaschitz G, Phan J, Little A, Abbott JR, Sun Q, Gmachl M, Rudolph D, Arnhof H, Rumpel K, Savarese F, Gerstberger T, Mischerikow N, Treu M, Herdeis L, Wunberg T, Gollner A, Weinstabl H, Mantoulidis A, Krämer O, McConnell DB, W Fesik S. Bröker J, et al. J Med Chem. 2022 Nov 10;65(21):14614-14629. doi: 10.1021/acs.jmedchem.2c01120. Epub 2022 Oct 27. J Med Chem. 2022. PMID: 36300829 Free PMC article.
Activating mutations in KRAS are the most frequent oncogenic alterations in cancer. The oncogenic hotspot position 12, located at the lip of the switch II pocket, offers a covalent attachment point for KRAS(G12C) inhibitors. ...
Activating mutations in KRAS are the most frequent oncogenic alterations in cancer. The oncogenic hotspot position 12, located at the lip …
Can public health policies on alcohol and tobacco reduce a cancer epidemic? Australia's experience.
Jiang H, Livingston M, Room R, Gan Y, English D, Chenhall R. Jiang H, et al. BMC Med. 2019 Nov 27;17(1):213. doi: 10.1186/s12916-019-1453-z. BMC Med. 2019. PMID: 31771596 Free PMC article.
METHODS: Annual population-based time-series data between 1911 and 2013 on per capita alcohol and tobacco consumption and head and neck (lip, oral cavity, pharynx, larynx and oesophagus), lung, breast, colorectum and anus, liver and total cancer mortality data from the 195 …
METHODS: Annual population-based time-series data between 1911 and 2013 on per capita alcohol and tobacco consumption and head and neck ( …