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Allosteric Inhibition of Parkinson's-Linked LRRK2 by Constrained Peptides.
ACS Chem Biol. 2021 Nov 19;16(11):2326-2338. doi: 10.1021/acschembio.1c00487. Epub 2021 Sep 8.
ACS Chem Biol. 2021.
PMID: 34496561
Free article.
LRRK2 dynamics analysis identifies allosteric control of the crosstalk between its catalytic domains.
Weng JH, Aoto PC, Lorenz R, Wu J, Schmidt SH, Manschwetus JT, Kaila-Sharma P, Silletti S, Mathea S, Chatterjee D, Knapp S, Herberg FW, Taylor SS.
Weng JH, et al. Among authors: manschwetus jt.
PLoS Biol. 2022 Feb 22;20(2):e3001427. doi: 10.1371/journal.pbio.3001427. eCollection 2022 Feb.
PLoS Biol. 2022.
PMID: 35192607
Free PMC article.
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A Stapled Peptide Mimic of the Pseudosubstrate Inhibitor PKI Inhibits Protein Kinase A.
Manschwetus JT, Bendzunas GN, Limaye AJ, Knape MJ, Herberg FW, Kennedy EJ.
Manschwetus JT, et al.
Molecules. 2019 Apr 20;24(8):1567. doi: 10.3390/molecules24081567.
Molecules. 2019.
PMID: 31009996
Free PMC article.
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Role of the leucine-rich repeat protein kinase 2 C-terminal tail in domain cross-talk.
Sharma PK, Weng JH, Manschwetus JT, Wu J, Ma W, Herberg FW, Taylor SS.
Sharma PK, et al. Among authors: manschwetus jt.
Biochem J. 2024 Feb 21;481(4):313-327. doi: 10.1042/BCJ20230477.
Biochem J. 2024.
PMID: 38305364
Free PMC article.
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Binding of the Human 14-3-3 Isoforms to Distinct Sites in the Leucine-Rich Repeat Kinase 2.
Manschwetus JT, Wallbott M, Fachinger A, Obergruber C, Pautz S, Bertinetti D, Schmidt SH, Herberg FW.
Manschwetus JT, et al.
Front Neurosci. 2020 Apr 7;14:302. doi: 10.3389/fnins.2020.00302. eCollection 2020.
Front Neurosci. 2020.
PMID: 32317922
Free PMC article.
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