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Showing results for jan lipinski
Search for Jan Lipenský instead (1 results)
Preface.
Lipinski RJ, Krauss RS. Lipinski RJ, et al. Curr Top Dev Biol. 2023;152:xi. doi: 10.1016/S0070-2153(23)00028-5. Curr Top Dev Biol. 2023. PMID: 36707216 No abstract available.
TCMSP: a database of systems pharmacology for drug discovery from herbal medicines.
Ru J, Li P, Wang J, Zhou W, Li B, Huang C, Li P, Guo Z, Tao W, Yang Y, Xu X, Li Y, Wang Y, Yang L. Ru J, et al. J Cheminform. 2014 Apr 16;6:13. doi: 10.1186/1758-2946-6-13. eCollection 2014. J Cheminform. 2014. PMID: 24735618 Free PMC article.
Twelve important ADME-related properties like human oral bioavailability, half-life, drug-likeness, Caco-2 permeability, blood-brain barrier and Lipinski's rule of five are provided for drug screening and evaluation. ...
Twelve important ADME-related properties like human oral bioavailability, half-life, drug-likeness, Caco-2 permeability, blood-brain barrier …
Going further than Lipinski's rule in drug design.
Walters WP. Walters WP. Expert Opin Drug Discov. 2012 Feb;7(2):99-107. doi: 10.1517/17460441.2012.648612. Epub 2012 Jan 13. Expert Opin Drug Discov. 2012. PMID: 22468912 Review.
INTRODUCTION: Lipinski's 1997 publication of the 'Rule of 5' (Ro5) was one of the most influential recent medicinal chemistry publications. ...The article also provides the reader with suggestions on future directions for the field. EXPERT OPINION: While Lipinski
INTRODUCTION: Lipinski's 1997 publication of the 'Rule of 5' (Ro5) was one of the most influential recent medicinal chemistry …
Eyes on Lipinski's Rule of Five: A New "Rule of Thumb" for Physicochemical Design Space of Ophthalmic Drugs.
Karami TK, Hailu S, Feng S, Graham R, Gukasyan HJ. Karami TK, et al. J Ocul Pharmacol Ther. 2022 Jan-Feb;38(1):43-55. doi: 10.1089/jop.2021.0069. Epub 2021 Dec 14. J Ocul Pharmacol Ther. 2022. PMID: 34905402 Free PMC article.
Unlike the methodology used to obtain molecular descriptors for assessment of drug-like properties by Lipinski's Rule of 5 (Ro5), this work presents a retrospective approach based on in silico analysis of molecular thermodynamic properties beyond Ro5 parameters (ie, …
Unlike the methodology used to obtain molecular descriptors for assessment of drug-like properties by Lipinski's Rule of 5 (Ro …
Cell Surface Transporters and Novel Drug Developments.
Carmichael N, Day PJR. Carmichael N, et al. Front Pharmacol. 2022 Mar 8;13:852938. doi: 10.3389/fphar.2022.852938. eCollection 2022. Front Pharmacol. 2022. PMID: 35350751 Free PMC article. Review.
Despite the numerous scientific and technological advances made within the last decade the attrition rates for new drug discovery remain as high as 95% for anticancer drugs. Recent drug development has been in part guided by Lipinski's Rule of 5 (Ro5) even though ma …
Despite the numerous scientific and technological advances made within the last decade the attrition rates for new drug discovery remain as …
Targeting "Undruggable" Proteins: Design of Synthetic Cyclopeptides.
Russo A, Aiello C, Grieco P, Marasco D. Russo A, et al. Curr Med Chem. 2016;23(8):748-62. doi: 10.2174/0929867323666160112122540. Curr Med Chem. 2016. PMID: 26758797 Review.
Typically macrocycles are 500-2000 Da in size, having 12-membered, or more, ring architecture: they do not obey the Lipinski's rule but, for them nature offers many examples as therapeutic agents such as erythromycin (antibiotic), cyclosporin (immunosuppressant) and …
Typically macrocycles are 500-2000 Da in size, having 12-membered, or more, ring architecture: they do not obey the Lipinski's
Anti-inflammatory Activity of PLA2 Inhibitory Saccharumoside-B.
Sadhu SP, Yarla NS, Pragada RR, Konduri P. Sadhu SP, et al. Antiinflamm Antiallergy Agents Med Chem. 2022;21(2):121-134. doi: 10.2174/1871523021666220330143058. Antiinflamm Antiallergy Agents Med Chem. 2022. PMID: 35362396
Saccharumoside-B potentially binds to the active site pocket of sPLA2 crystal protein (binding energy -7.6 Kcal/Mol). It complies with Lipinski's Rule of Five, showing a promising safety profile. The bioactivity scores suggested it to be a better enzyme inhibitor. . …
Saccharumoside-B potentially binds to the active site pocket of sPLA2 crystal protein (binding energy -7.6 Kcal/Mol). It complies with Li
Design Principles for Intestinal Permeability of Cyclic Peptides.
Mathiowetz AM. Mathiowetz AM. Methods Mol Biol. 2019;2001:1-15. doi: 10.1007/978-1-4939-9504-2_1. Methods Mol Biol. 2019. PMID: 31134564 Review.
One of the most exciting facets of cyclic peptides is that they have the potential to be orally bioavailable, despite having physical properties well beyond the traditional "Rule-of-5" chemistry space (Lipinski et al., Adv Drug Deliv Rev. 23(1): 3-25, 1997). An important c …
One of the most exciting facets of cyclic peptides is that they have the potential to be orally bioavailable, despite having physical proper …
Passive delivery of protein drugs through transdermal route.
Chaulagain B, Jain A, Tiwari A, Verma A, Jain SK. Chaulagain B, et al. Artif Cells Nanomed Biotechnol. 2018;46(sup1):472-487. doi: 10.1080/21691401.2018.1430695. Epub 2018 Jan 29. Artif Cells Nanomed Biotechnol. 2018. PMID: 29378433 Review.
Stratum corneum residing on the uppermost layer of the skin provides a tough barrier to transport the drugs across the skin. Very small group of drugs sharing Lipinski properties, i.e. drugs having molecular weight not larger than 500 Da, having high lipophilicity and opti …
Stratum corneum residing on the uppermost layer of the skin provides a tough barrier to transport the drugs across the skin. Very small grou …
Key Considerations in Targeted Protein Degradation Drug Discovery and Development.
Qin L, Dai H, Wang J. Qin L, et al. Front Chem. 2022 Aug 1;10:934337. doi: 10.3389/fchem.2022.934337. eCollection 2022. Front Chem. 2022. PMID: 35978859 Free PMC article. Review.
For the development of targeted protein degraders to meet therapeutic needs, several aspects will be considered, namely, the selective degradation of disease-causing proteins, the oral bioavailability of degraders beyond Lipinski's rule of five (bRo5) scope, demands …
For the development of targeted protein degraders to meet therapeutic needs, several aspects will be considered, namely, the selective degra …
1,126 results