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Who is a 'healthy subject'?-consensus results on pivotal eligibility criteria for clinical trials.
Breithaupt-Groegler K, Coch C, Coenen M, Donath F, Erb-Zohar K, Francke K, Goehler K, Iovino M, Kammerer KP, Mikus G, Rengelshausen J, Sourgens H, Schinzel R, Sudhop T, Wensing G. Breithaupt-Groegler K, et al. Eur J Clin Pharmacol. 2017 Apr;73(4):409-416. doi: 10.1007/s00228-016-2189-8. Epub 2017 Jan 7. Eur J Clin Pharmacol. 2017. PMID: 28064353 Free PMC article. Review.
Synchronous x-ray and radio mode switches: a rapid global transformation of the pulsar magnetosphere.
Hermsen W, Hessels JW, Kuiper L, van Leeuwen J, Mitra D, de Plaa J, Rankin JM, Stappers BW, Wright GA, Basu R, Alexov A, Coenen T, Grießmeier JM, Hassall TE, Karastergiou A, Keane E, Kondratiev VI, Kramer M, Kuniyoshi M, Noutsos A, Serylak M, Pilia M, Sobey C, Weltevrede P, Zagkouris K, Asgekar A, Avruch IM, Batejat F, Bell ME, Bell MR, Bentum MJ, Bernardi G, Best P, Bîrzan L, Bonafede A, Breitling F, Broderick J, Brüggen M, Butcher HR, Ciardi B, Duscha S, Eislöffel J, Falcke H, Fender R, Ferrari C, Frieswijk W, Garrett MA, de Gasperin F, de Geus E, Gunst AW, Heald G, Hoeft M, Horneffer A, Iacobelli M, Kuper G, Maat P, Macario G, Markoff S, McKean JP, Mevius M, Miller-Jones JC, Morganti R, Munk H, Orrú E, Paas H, Pandey-Pommier M, Pandey VN, Pizzo R, Polatidis AG, Rawlings S, Reich W, Röttgering H, Scaife AM, Schoenmakers A, Shulevski A, Sluman J, Steinmetz M, Tagger M, Tang Y, Tasse C, ter Veen S, Vermeulen R, van de Brink RH, van Weeren RJ, Wijers RA, Wise MW, Wucknitz O, Yatawatta S, Zarka P. Hermsen W, et al. Science. 2013 Jan 25;339(6118):436-9. doi: 10.1126/science.1230960. Science. 2013. PMID: 23349288 Free article.
TYK2 protein-coding variants protect against rheumatoid arthritis and autoimmunity, with no evidence of major pleiotropic effects on non-autoimmune complex traits.
Diogo D, Bastarache L, Liao KP, Graham RR, Fulton RS, Greenberg JD, Eyre S, Bowes J, Cui J, Lee A, Pappas DA, Kremer JM, Barton A, Coenen MJ, Franke B, Kiemeney LA, Mariette X, Richard-Miceli C, Canhão H, Fonseca JE, de Vries N, Tak PP, Crusius JB, Nurmohamed MT, Kurreeman F, Mikuls TR, Okada Y, Stahl EA, Larson DE, Deluca TL, O'Laughlin M, Fronick CC, Fulton LL, Kosoy R, Ransom M, Bhangale TR, Ortmann W, Cagan A, Gainer V, Karlson EW, Kohane I, Murphy SN, Martin J, Zhernakova A, Klareskog L, Padyukov L, Worthington J, Mardis ER, Seldin MF, Gregersen PK, Behrens T, Raychaudhuri S, Denny JC, Plenge RM. Diogo D, et al. PLoS One. 2015 Apr 7;10(4):e0122271. doi: 10.1371/journal.pone.0122271. eCollection 2015. PLoS One. 2015. PMID: 25849893 Free PMC article.