Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1955 1
1958 4
1959 1
1961 1
1962 1
1963 1
1965 4
1966 1
1967 1
1968 4
1969 3
1970 4
1971 6
1972 7
1973 1
1974 1
1975 4
1976 4
1977 2
1978 2
1979 3
1980 3
1981 5
1982 3
1983 3
1984 4
1985 1
1986 4
1987 5
1988 2
1989 4
1990 1
1991 3
1992 1
1993 3
1995 1
1996 4
1997 5
1999 3
2000 1
2001 5
2002 5
2003 5
2004 7
2005 6
2006 11
2007 17
2008 9
2009 5
2010 15
2011 33
2012 39
2013 41
2014 47
2015 52
2016 73
2017 84
2018 68
2019 70
2020 99
2021 145
2022 125
2023 130
2024 55

Text availability

Article attribute

Article type

Publication date

Search Results

1,113 results

Results by year

Filters applied: . Clear all
Page 1
Showing results for jan lipinski
Search for Jan Lipenský instead (1 results)
Preface.
Lipinski RJ, Krauss RS. Lipinski RJ, et al. Curr Top Dev Biol. 2023;152:xi. doi: 10.1016/S0070-2153(23)00028-5. Curr Top Dev Biol. 2023. PMID: 36707216 No abstract available.
TCMSP: a database of systems pharmacology for drug discovery from herbal medicines.
Ru J, Li P, Wang J, Zhou W, Li B, Huang C, Li P, Guo Z, Tao W, Yang Y, Xu X, Li Y, Wang Y, Yang L. Ru J, et al. J Cheminform. 2014 Apr 16;6:13. doi: 10.1186/1758-2946-6-13. eCollection 2014. J Cheminform. 2014. PMID: 24735618 Free PMC article.
Twelve important ADME-related properties like human oral bioavailability, half-life, drug-likeness, Caco-2 permeability, blood-brain barrier and Lipinski's rule of five are provided for drug screening and evaluation. ...
Twelve important ADME-related properties like human oral bioavailability, half-life, drug-likeness, Caco-2 permeability, blood-brain barrier …
Going further than Lipinski's rule in drug design.
Walters WP. Walters WP. Expert Opin Drug Discov. 2012 Feb;7(2):99-107. doi: 10.1517/17460441.2012.648612. Epub 2012 Jan 13. Expert Opin Drug Discov. 2012. PMID: 22468912 Review.
INTRODUCTION: Lipinski's 1997 publication of the 'Rule of 5' (Ro5) was one of the most influential recent medicinal chemistry publications. ...The article also provides the reader with suggestions on future directions for the field. EXPERT OPINION: While Lipinski
INTRODUCTION: Lipinski's 1997 publication of the 'Rule of 5' (Ro5) was one of the most influential recent medicinal chemistry …
Eyes on Lipinski's Rule of Five: A New "Rule of Thumb" for Physicochemical Design Space of Ophthalmic Drugs.
Karami TK, Hailu S, Feng S, Graham R, Gukasyan HJ. Karami TK, et al. J Ocul Pharmacol Ther. 2022 Jan-Feb;38(1):43-55. doi: 10.1089/jop.2021.0069. Epub 2021 Dec 14. J Ocul Pharmacol Ther. 2022. PMID: 34905402 Free PMC article.
Unlike the methodology used to obtain molecular descriptors for assessment of drug-like properties by Lipinski's Rule of 5 (Ro5), this work presents a retrospective approach based on in silico analysis of molecular thermodynamic properties beyond Ro5 parameters (ie, …
Unlike the methodology used to obtain molecular descriptors for assessment of drug-like properties by Lipinski's Rule of 5 (Ro …
Sodium Selenite as an Anticancer Agent.
Lipinski B. Lipinski B. Anticancer Agents Med Chem. 2017;17(5):658-661. doi: 10.2174/1871520616666160607011024. Anticancer Agents Med Chem. 2017. PMID: 27281365 Review.
Cell Surface Transporters and Novel Drug Developments.
Carmichael N, Day PJR. Carmichael N, et al. Front Pharmacol. 2022 Mar 8;13:852938. doi: 10.3389/fphar.2022.852938. eCollection 2022. Front Pharmacol. 2022. PMID: 35350751 Free PMC article. Review.
Despite the numerous scientific and technological advances made within the last decade the attrition rates for new drug discovery remain as high as 95% for anticancer drugs. Recent drug development has been in part guided by Lipinski's Rule of 5 (Ro5) even though ma …
Despite the numerous scientific and technological advances made within the last decade the attrition rates for new drug discovery remain as …
Virtual screening of acetylcholinesterase inhibitors using the Lipinski's rule of five and ZINC databank.
Nogara PA, Saraiva Rde A, Caeran Bueno D, Lissner LJ, Lenz Dalla Corte C, Braga MM, Rosemberg DB, Rocha JB. Nogara PA, et al. Biomed Res Int. 2015;2015:870389. doi: 10.1155/2015/870389. Epub 2015 Jan 22. Biomed Res Int. 2015. PMID: 25685814 Free PMC article.
One of the methods used to treat AD is the increase of acetylcholine (ACh) in the brain by using acetylcholinesterase inhibitors (AChEIs). In this study, we used the ZINC databank and the Lipinski's rule of five to perform a virtual screening and a molecular docking …
One of the methods used to treat AD is the increase of acetylcholine (ACh) in the brain by using acetylcholinesterase inhibitors (AChEIs). I …
Design Principles for Intestinal Permeability of Cyclic Peptides.
Mathiowetz AM. Mathiowetz AM. Methods Mol Biol. 2019;2001:1-15. doi: 10.1007/978-1-4939-9504-2_1. Methods Mol Biol. 2019. PMID: 31134564 Review.
One of the most exciting facets of cyclic peptides is that they have the potential to be orally bioavailable, despite having physical properties well beyond the traditional "Rule-of-5" chemistry space (Lipinski et al., Adv Drug Deliv Rev. 23(1): 3-25, 1997). An important c …
One of the most exciting facets of cyclic peptides is that they have the potential to be orally bioavailable, despite having physical proper …
1,113 results