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Page 1
Showing results for jade roles
Search for Jade Ryles instead (3 results)
Phase 3 efficacy and safety of abrocitinib in adults with moderate-to-severe atopic dermatitis after switching from dupilumab (JADE EXTEND).
Shi VY, Bhutani T, Fonacier L, Deleuran M, Shumack S, Valdez H, Zhang F, Chan GL, Cameron MC, Yin NC. Shi VY, et al. J Am Acad Dermatol. 2022 Aug;87(2):351-358. doi: 10.1016/j.jaad.2022.04.009. Epub 2022 Apr 16. J Am Acad Dermatol. 2022. PMID: 35439608 Free article. Clinical Trial.
METHODS: Patients with moderate-to-severe atopic dermatitis received abrocitinib 200 mg or 100 mg once daily in JADE EXTEND (phase 3 extension) after dupilumab in double-blind, placebo-controlled phase 3 JADE COMPARE. ...LIMITATIONS: Short-term, 12-week analysis; no …
METHODS: Patients with moderate-to-severe atopic dermatitis received abrocitinib 200 mg or 100 mg once daily in JADE EXTEND (phase 3 …
Activating cGAS-STING axis contributes to neuroinflammation in CVST mouse model and induces inflammasome activation and microglia pyroptosis.
Ding R, Li H, Liu Y, Ou W, Zhang X, Chai H, Huang X, Yang W, Wang Q. Ding R, et al. J Neuroinflammation. 2022 Jun 10;19(1):137. doi: 10.1186/s12974-022-02511-0. J Neuroinflammation. 2022. PMID: 35689216 Free PMC article.
The cyclic GMP-AMP synthase-stimulator of interferon gene (cGAS-STING) axis is a cytoplasmic double-stranded DNA (dsDNA) sensing pathway has recently emerged as a crucial mediator of neuroinflammation in ischemic stroke. However, the role of the cGAS-STING pathway in modul …
The cyclic GMP-AMP synthase-stimulator of interferon gene (cGAS-STING) axis is a cytoplasmic double-stranded DNA (dsDNA) sensing pathway has …
Mer regulates microglial/macrophage M1/M2 polarization and alleviates neuroinflammation following traumatic brain injury.
Wu H, Zheng J, Xu S, Fang Y, Wu Y, Zeng J, Shao A, Shi L, Lu J, Mei S, Wang X, Guo X, Wang Y, Zhao Z, Zhang J. Wu H, et al. J Neuroinflammation. 2021 Jan 5;18(1):2. doi: 10.1186/s12974-020-02041-7. J Neuroinflammation. 2021. PMID: 33402181 Free PMC article.
However, its function in regulating the innate immune response and microglial/macrophage M1/M2 polarization in TBI has not been addressed. The present study aimed to evaluate the role of Mer in regulating microglial/macrophage M1/M2 polarization and neuroinflammation follo …
However, its function in regulating the innate immune response and microglial/macrophage M1/M2 polarization in TBI has not been addressed. T …
Jade-1: its structure, regulation and functions in the renal cancer.
Zhang YC, Du WQ, Zhang RY, Zheng JN, Pei DS. Zhang YC, et al. Curr Mol Med. 2016;16(1):63-9. doi: 10.2174/1566524016666151222144511. Curr Mol Med. 2016. PMID: 26695694 Review.
Jade-1 is also deemed to be a candidate of transcriptional co-activator associated with histone acetyltransferase (HAT) activity. This review focuses on the anticancer role of Jade-1 in clear cell renal carcinoma and the inhibitory effect of Jade-1 on …
Jade-1 is also deemed to be a candidate of transcriptional co-activator associated with histone acetyltransferase (HAT) activity. Thi …
High-intensity interval training ameliorates Alzheimer's disease-like pathology by regulating astrocyte phenotype-associated AQP4 polarization.
Feng S, Wu C, Zou P, Deng Q, Chen Z, Li M, Zhu L, Li F, Liu TC, Duan R, Yang L. Feng S, et al. Theranostics. 2023 Jun 4;13(10):3434-3450. doi: 10.7150/thno.81951. eCollection 2023. Theranostics. 2023. PMID: 37351177 Free PMC article.
The astrocyte AQP4 polarized distribution-mediated glymphatic system is essential for Abeta and abnormal tau clearance and is a potential therapeutic target for AD. However, the role of exercise on the AQP4 polarized distribution and the association between the AQP4 polari …
The astrocyte AQP4 polarized distribution-mediated glymphatic system is essential for Abeta and abnormal tau clearance and is a potential th …
Inhibition of ferroptosis attenuates tissue damage and improves long-term outcomes after traumatic brain injury in mice.
Xie BS, Wang YQ, Lin Y, Mao Q, Feng JF, Gao GY, Jiang JY. Xie BS, et al. CNS Neurosci Ther. 2019 Apr;25(4):465-475. doi: 10.1111/cns.13069. Epub 2018 Sep 28. CNS Neurosci Ther. 2019. PMID: 30264934 Free PMC article.
AIMS: Ferroptosis, a new form of iron-dependent programmed cell death, has been shown to be involved in a range of diseases. However, the role of ferroptosis in traumatic brain injury (TBI) has yet to be elucidated. ...METHODS: After establishing the TBI model in mice, we …
AIMS: Ferroptosis, a new form of iron-dependent programmed cell death, has been shown to be involved in a range of diseases. However, the …
Structure, function and regulation of jade family PHD finger 1 (JADE1).
Panchenko MV. Panchenko MV. Gene. 2016 Sep 1;589(1):1-11. doi: 10.1016/j.gene.2016.05.002. Epub 2016 May 4. Gene. 2016. PMID: 27155521 Free PMC article. Review.
All three JADE proteins bear in tandem two Plant Homeo-domains (PHD) which are zinc finger domains. This review focuses on one member of the JADE family, JADE1. Studies addressing the biochemical, cellular and biological role of JADE1 are discussed. ...
All three JADE proteins bear in tandem two Plant Homeo-domains (PHD) which are zinc finger domains. This review focuses on one member …
Detection strategies for superoxide anion: A review.
Jie Z, Liu J, Shu M, Ying Y, Yang H. Jie Z, et al. Talanta. 2022 Jan 1;236:122892. doi: 10.1016/j.talanta.2021.122892. Epub 2021 Sep 20. Talanta. 2022. PMID: 34635271 Review.
Reactive oxygen species (ROS) play an essential role in regulating various physiological functions of living organisms. ...
Reactive oxygen species (ROS) play an essential role in regulating various physiological functions of living organisms. ...
Caveolae: One Function or Many?
Cheng JPX, Nichols BJ. Cheng JPX, et al. Trends Cell Biol. 2016 Mar;26(3):177-189. doi: 10.1016/j.tcb.2015.10.010. Epub 2015 Dec 1. Trends Cell Biol. 2016. PMID: 26653791 Review.
New data also support a model in which the central function of caveolae could be related to the protection of cells from mechanical stress within the plasma membrane. We present evidence for these diverse roles and consider in vitro and in vivo experiments confirming a mec …
New data also support a model in which the central function of caveolae could be related to the protection of cells from mechanical stress w …
Unraveling the signaling roles of indole in an opportunistic pathogen Pseudomonas aeruginosa strain Jade-X.
Zhang J, Ma Q, Wang C, Meng N. Zhang J, et al. Chemosphere. 2024 Mar;352:141482. doi: 10.1016/j.chemosphere.2024.141482. Epub 2024 Feb 20. Chemosphere. 2024. PMID: 38387666
Herein, the impacts of indole on a newly isolated P. aeruginosa strain Jade-X were systematically investigated. Indole (0.5-2.0 mM) enhanced the biofilm production by 1.33-2.31-fold after 24 h incubation at 30 C. ...This study should provide new insights into our understan …
Herein, the impacts of indole on a newly isolated P. aeruginosa strain Jade-X were systematically investigated. Indole (0.5-2.0 mM) e …
482 results