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Modulation of taxane binding to tubulin curved and straight conformations by systematic 3'N modification provides for improved microtubule binding, persistent cytotoxicity and in vivo potency.
Eur J Med Chem. 2023 Nov 5;259:115668. doi: 10.1016/j.ejmech.2023.115668. Epub 2023 Jul 19.
Eur J Med Chem. 2023.
PMID: 37490800
Yuanhuacine Is a Potent and Selective Inhibitor of the Basal-Like 2 Subtype of Triple Negative Breast Cancer with Immunogenic Potential.
Fermaintt CS, Peramuna T, Cai S, Takahashi-Ruiz L, Essif JN, Grant CV, O'Keefe BR, Mooberry SL, Cichewicz RH, Risinger AL.
Fermaintt CS, et al. Among authors: essif jn.
Cancers (Basel). 2021 Jun 7;13(11):2834. doi: 10.3390/cancers13112834.
Cancers (Basel). 2021.
PMID: 34200174
Free PMC article.
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