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Page 1
Lack of P4H-TM in mice results in age-related retinal and renal alterations.
Hum Mol Genet. 2016 Sep 1;25(17):3810-3823. doi: 10.1093/hmg/ddw228. Epub 2016 Jul 27.
Hum Mol Genet. 2016.
PMID: 27466183
Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury.
Hyvärinen J, Hassinen IE, Sormunen R, Mäki JM, Kivirikko KI, Koivunen P, Myllyharju J.
Hyvärinen J, et al.
J Biol Chem. 2010 Apr 30;285(18):13646-57. doi: 10.1074/jbc.M109.084855. Epub 2010 Feb 25.
J Biol Chem. 2010.
PMID: 20185832
Free PMC article.
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An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor alpha.
Koivunen P, Tiainen P, Hyvärinen J, Williams KE, Sormunen R, Klaus SJ, Kivirikko KI, Myllyharju J.
Koivunen P, et al. Among authors: hyvarinen j.
J Biol Chem. 2007 Oct 19;282(42):30544-52. doi: 10.1074/jbc.M704988200. Epub 2007 Aug 27.
J Biol Chem. 2007.
PMID: 17726031
Free article.
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Deficiency of a transmembrane prolyl 4-hydroxylase in the zebrafish leads to basement membrane defects and compromised kidney function.
Hyvärinen J, Parikka M, Sormunen R, Rämet M, Tryggvason K, Kivirikko KI, Myllyharju J, Koivunen P.
Hyvärinen J, et al.
J Biol Chem. 2010 Dec 31;285(53):42023-32. doi: 10.1074/jbc.M110.145904. Epub 2010 Oct 15.
J Biol Chem. 2010.
PMID: 20952382
Free PMC article.
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Differences in hydroxylation and binding of Notch and HIF-1alpha demonstrate substrate selectivity for factor inhibiting HIF-1 (FIH-1).
Wilkins SE, Hyvärinen J, Chicher J, Gorman JJ, Peet DJ, Bilton RL, Koivunen P.
Wilkins SE, et al. Among authors: hyvarinen j.
Int J Biochem Cell Biol. 2009 Jul;41(7):1563-71. doi: 10.1016/j.biocel.2009.01.005. Epub 2009 Jan 20.
Int J Biochem Cell Biol. 2009.
PMID: 19401150
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