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Rapid-deployment aortic valve replacement versus standard bioprosthesis implantation.
Ferrari E, Roduit C, Salamin P, Caporali E, Demertzis S, Tozzi P, Berdajs D, von Segesser L. Ferrari E, et al. J Card Surg. 2017 Jun;32(6):322-327. doi: 10.1111/jocs.13139. Epub 2017 May 11. J Card Surg. 2017. PMID: 28493342

RESULTS: There were more female patients in the Intuity-group (47% vs 22%, p = 0.035); mean age was 78 5.6 and 72.5 6 years in the Intuity-group and Perimount-group (p < 0.001); coronary disease was more common in the Intuity-group (65% vs 25%, p = 0.005).

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RESULTS: There were more female patients in the Intuity-group (47% vs 22%, p = 0.035); mean age was 78 5.6 and 72.5 6 years in the In …
Immune Responsiveness to LPS Determines Risk of Childhood Wheeze and Asthma in 17q21 Risk Allele Carriers.
Illi S, Depner M, Pfefferle PI, Renz H, Roduit C, Taft DH, Kalanetra KM, Mills DA, Farquharson FM, Louis P, Schmausser-Hechfellner E, Divaret-Chauveau A, Lauener R, Karvonen AM, Pekkanen J, Kirjavainen PV, Roponen M, Riedler J, Kabesch M, Schaub B, von Mutius E; PASTURE Study Group. Illi S, et al. Am J Respir Crit Care Med. 2022 Mar 15;205(6):641-650. doi: 10.1164/rccm.202106-1458OC. Am J Respir Crit Care Med. 2022. PMID: 34919021
When classifying detectability of cytokines by latent class analysis, carrying the 17q21 risk allele rs7216389 was associated with risk of wheeze only in the class with the lowest level of LPS-induced activation: odds ratio (OR), 1.89; 95% confidence interval [CI], 1.13-3.16; …
When classifying detectability of cytokines by latent class analysis, carrying the 17q21 risk allele rs7216389 was associated with risk of w …
Clinical and epidemiologic phenotypes of childhood asthma.
Depner M, Fuchs O, Genuneit J, Karvonen AM, Hyvärinen A, Kaulek V, Roduit C, Weber J, Schaub B, Lauener R, Kabesch M, Pfefferle PI, Frey U, Pekkanen J, Dalphin JC, Riedler J, Braun-Fahrländer C, von Mutius E, Ege MJ; PASTURE Study Group. Depner M, et al. Am J Respir Crit Care Med. 2014 Jan 15;189(2):129-38. doi: 10.1164/rccm.201307-1198OC. Am J Respir Crit Care Med. 2014. PMID: 24283801
The latter identified a subgroup of children with decreased lung function, increased genetic risk, and in utero smoke exposure (ODDS RATIO, 2.03; 95% CONFIDENCE INTERVAL, 1.12-3.68; P = 0.0191), but without established asthma diagnosis and treatment. ...
The latter identified a subgroup of children with decreased lung function, increased genetic risk, and in utero smoke exposure (ODDS RATIO, …
CNGB3 Missense Variant Causes Recessive Achromatopsia in Original Braunvieh Cattle.
Häfliger IM, Marchionatti E, Stengård M, Wolf-Hofstetter S, Paris JM, Jacinto JGP, Watté C, Voelter K, Occelli LM, Komáromy AM, Oevermann A, Goepfert C, Borgo A, Roduit R, Spengeler M, Seefried FR, Drögemüller C. Häfliger IM, et al. Int J Mol Sci. 2021 Nov 18;22(22):12440. doi: 10.3390/ijms222212440. Int J Mol Sci. 2021. PMID: 34830323 Free PMC article.
We identified a single missense variant in the bovine CNGB3 gene situated in a ~2.5 Mb homozygous genome region on chromosome 14 shared between all cases. All affected cattle were homozygous carriers of the p.Asp251Asn mutation that was predicted to be deleterious, affecti …
We identified a single missense variant in the bovine CNGB3 gene situated in a ~2.5 Mb homozygous genome region on chromosome 14 shared betw …
The personality traits activity, self-reproach, and negative affect jointly predict clinical recurrence, depressive symptoms, and low quality of life in inflammatory bowel disease patients.
Jordi SBU, Lang BM, Wyss J, Auschra B, Yilmaz B, Krupka N, Greuter T, Schreiner P, Biedermann L, Preisig M, von Känel R, Rogler G, Begré S, Misselwitz B; Swiss IBD cohort study group. Jordi SBU, et al. J Gastroenterol. 2022 Nov;57(11):848-866. doi: 10.1007/s00535-022-01902-7. Epub 2022 Jul 28. J Gastroenterol. 2022. PMID: 35900592 Free PMC article.
RESULTS: In time-to-event analyses, a high NEO-FFI risk score was predictive for the clinical endpoints of new extraintestinal manifestation [EIM, adjusted hazard ratio (aHR) = 1.64, corrected p value (q) = 0.036] and two established composite flare endpoints (aHR = 1.53-1 …
RESULTS: In time-to-event analyses, a high NEO-FFI risk score was predictive for the clinical endpoints of new extraintestinal manifestation …
TNF-α-induced protein 3 is a key player in childhood asthma development and environment-mediated protection.
Krusche J, Twardziok M, Rehbach K, Böck A, Tsang MS, Schröder PC, Kumbrink J, Kirchner T, Xing Y, Riedler J, Dalphin JC, Pekkanen J, Lauener R, Roponen M, Li J, Wong CK, Wong GWK, Schaub B; PASTURE study group. Krusche J, et al. J Allergy Clin Immunol. 2019 Dec;144(6):1684-1696.e12. doi: 10.1016/j.jaci.2019.07.029. Epub 2019 Aug 2. J Allergy Clin Immunol. 2019. PMID: 31381928 Clinical Trial.

RESULTS: Anti-inflammatory TNFAIP3 gene and protein expression was consistently decreased, whereas proinflammatory Toll-like receptor 4 expression was increased in urban asthmatic patients (P < .05), reflecting their increased inflammatory status. Ex vivo farm dust or L

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RESULTS: Anti-inflammatory TNFAIP3 gene and protein expression was consistently decreased, whereas proinflammatory Toll-like receptor 4 expr …
Prenatal and early-life exposures alter expression of innate immunity genes: the PASTURE cohort study.
Loss G, Bitter S, Wohlgensinger J, Frei R, Roduit C, Genuneit J, Pekkanen J, Roponen M, Hirvonen MR, Dalphin JC, Dalphin ML, Riedler J, von Mutius E, Weber J, Kabesch M, Michel S, Braun-Fahrländer C, Lauener R; PASTURE study group. Loss G, et al. J Allergy Clin Immunol. 2012 Aug;130(2):523-30.e9. doi: 10.1016/j.jaci.2012.05.049. J Allergy Clin Immunol. 2012. PMID: 22846753
RESULTS: Gene expression of innate immunity receptors in cord blood was overall higher in neonates of farmers (P for multifactorial multivariate ANOVA= .041), significantly so for TLR7 (adjusted geometric means ratio [aGMR], 1.15; 95% CI, 1.02-1.30) and TLR8 (aGMR, 1.15; 9 …
RESULTS: Gene expression of innate immunity receptors in cord blood was overall higher in neonates of farmers (P for multifactorial m …
11 results