Human thymopoiesis produces polyspecific CD8+ α/β T cells responding to multiple viral antigens.
Quiniou V, Barennes P, Mhanna V, Stys P, Vantomme H, Zhou Z, Martina F, Coatnoan N, Barbie M, Pham HP, Clémenceau B, Vie H, Shugay M, Six A, Brandao B, Mallone R, Mariotti-Ferrandiz E, Klatzmann D.
Quiniou V, et al.
Elife. 2023 Mar 30;12:e81274. doi: 10.7554/eLife.81274.
Elife. 2023.
PMID: 36995951
Free PMC article.
We show here that human thymopoiesis releases a large population of clustered CD8(+) T cells harboring alpha/beta paired TCRs that (i) have high generation probabilities and (ii) a preferential usage of some V and J genes, (iii) which CDR3 are shared between individuals, a …
We show here that human thymopoiesis releases a large population of clustered CD8(+) T cells harboring alpha/beta paired TCRs that (i) have …