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Page 1
New features of vault architecture and dynamics revealed by novel refinement using the deformable elastic network approach.
Casañas A, Querol-Audí J, Guerra P, Pous J, Tanaka H, Tsukihara T, Verdaguer N, Fita I. Casañas A, et al. Acta Crystallogr D Biol Crystallogr. 2013 Jun;69(Pt 6):1054-61. doi: 10.1107/S0907444913004472. Epub 2013 May 14. Acta Crystallogr D Biol Crystallogr. 2013. PMID: 23695250 Free article.
A 2.1 A resolution structure of the seven N-terminal repeats (R1-7) of MVP has also been determined [Querol-Audi et al. (2009), EMBO J. 28, 3450-3457], revealing important discrepancies with respect to the MVP models for repeats R1 and R2. ...
A 2.1 A resolution structure of the seven N-terminal repeats (R1-7) of MVP has also been determined [Querol-Audi et al. (2009) …
A novel benzonitrile analogue inhibits rhinovirus replication.
Lacroix C, Querol-Audí J, Roche M, Franco D, Froeyen M, Guerra P, Terme T, Vanelle P, Verdaguer N, Neyts J, Leyssen P. Lacroix C, et al. J Antimicrob Chemother. 2014 Oct;69(10):2723-32. doi: 10.1093/jac/dku200. Epub 2014 Jun 19. J Antimicrob Chemother. 2014. PMID: 24948704
Architecture of human translation initiation factor 3.
Querol-Audi J, Sun C, Vogan JM, Smith MD, Gu Y, Cate JH, Nogales E. Querol-Audi J, et al. Structure. 2013 Jun 4;21(6):920-8. doi: 10.1016/j.str.2013.04.002. Epub 2013 Apr 25. Structure. 2013. PMID: 23623729 Free PMC article.
We further show that eIF3 subunits a and c interact with initiation factors eIF1 and eIF1A, which control the stringency of start codon selection. Finally, we find that subunit j, which modulates messenger RNA interactions with the small ribosomal subunit, makes multiple i …
We further show that eIF3 subunits a and c interact with initiation factors eIF1 and eIF1A, which control the stringency of start codon sele …
Activation mechanism of a noncanonical RNA-dependent RNA polymerase.
Garriga D, Navarro A, Querol-Audí J, Abaitua F, Rodríguez JF, Verdaguer N. Garriga D, et al. Proc Natl Acad Sci U S A. 2007 Dec 18;104(51):20540-5. doi: 10.1073/pnas.0704447104. Epub 2007 Dec 11. Proc Natl Acad Sci U S A. 2007. PMID: 18077388 Free PMC article.
Phylogenetic analyses indicate that both lineages diverged at a very early stage of the evolution of the enzyme [Gorbalenya AE, Pringle FM, Zeddam JL, Luke BT, Cameron CE, Kalmakoff J, Hanzlik TN, Gordon KH, Ward VK (2002) J Mol Biol 324:47-62]. ...
Phylogenetic analyses indicate that both lineages diverged at a very early stage of the evolution of the enzyme [Gorbalenya AE, Pringle FM, …