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Page 1
Ustekinumab as Induction and Maintenance Therapy for Crohn's Disease.
Feagan BG, Sandborn WJ, Gasink C, Jacobstein D, Lang Y, Friedman JR, Blank MA, Johanns J, Gao LL, Miao Y, Adedokun OJ, Sands BE, Hanauer SB, Vermeire S, Targan S, Ghosh S, de Villiers WJ, Colombel JF, Tulassay Z, Seidler U, Salzberg BA, Desreumaux P, Lee SD, Loftus EV Jr, Dieleman LA, Katz S, Rutgeerts P; UNITI–IM-UNITI Study Group. Feagan BG, et al. N Engl J Med. 2016 Nov 17;375(20):1946-1960. doi: 10.1056/NEJMoa1602773. N Engl J Med. 2016. PMID: 27959607 Free article. Clinical Trial.
RESULTS: The rates of response at week 6 among patients receiving intravenous ustekinumab at a dose of either 130 mg or approximately 6 mg per kilogram were significantly higher than the rates among patients receiving placebo (in UNITI-1, 34.3%, 33.7%, and 21.5%, respectively, wi …
RESULTS: The rates of response at week 6 among patients receiving intravenous ustekinumab at a dose of either 130 mg or approximately 6 mg p …
Tranexamic Acid in Patients Undergoing Coronary-Artery Surgery.
Myles PS, Smith JA, Forbes A, Silbert B, Jayarajah M, Painter T, Cooper DJ, Marasco S, McNeil J, Bussières JS, McGuinness S, Byrne K, Chan MT, Landoni G, Wallace S; ATACAS Investigators of the ANZCA Clinical Trials Network. Myles PS, et al. N Engl J Med. 2017 Jan 12;376(2):136-148. doi: 10.1056/NEJMoa1606424. Epub 2016 Oct 23. N Engl J Med. 2017. PMID: 27774838 Free article. Clinical Trial.
A primary outcome event occurred in 386 patients (16.7%) in the tranexamic acid group and in 420 patients (18.1%) in the placebo group (relative risk, 0.92; 95% confidence interval, 0.81 to 1.05; P=0.22). The total number of units of blood products that were transfused dur …
A primary outcome event occurred in 386 patients (16.7%) in the tranexamic acid group and in 420 patients (18.1%) in the placebo group (rela …
A Mediterranean Diet Pattern Improves Intestinal Inflammation Concomitant with Reshaping of the Bacteriome in Ulcerative Colitis: A Randomised Controlled Trial.
Haskey N, Estaki M, Ye J, Shim RK, Singh S, Dieleman LA, Jacobson K, Gibson DL. Haskey N, et al. J Crohns Colitis. 2023 Nov 8;17(10):1569-1578. doi: 10.1093/ecco-jcc/jjad073. J Crohns Colitis. 2023. PMID: 37095601 Free PMC article. Clinical Trial.
The MDP group had higher levels of total faecal short chain fatty acids [SCFAs] [p = 0.01], acetic acid [p = 0.03], and butyric acid [p = 0.03] compared with the CHD. ...
The MDP group had higher levels of total faecal short chain fatty acids [SCFAs] [p = 0.01], acetic acid [p = 0.03], and butyri …
Recommendations for Probiotic Use--2015 Update: Proceedings and Consensus Opinion.
Floch MH, Walker WA, Sanders ME, Nieuwdorp M, Kim AS, Brenner DA, Qamar AA, Miloh TA, Guarino A, Guslandi M, Dieleman LA, Ringel Y, Quigley EM, Brandt LJ. Floch MH, et al. J Clin Gastroenterol. 2015 Nov-Dec;49 Suppl 1:S69-73. doi: 10.1097/MCG.0000000000000420. J Clin Gastroenterol. 2015. PMID: 26447969
Bosentan, an endothelin receptor antagonist, reduces leucocyte adhesion and inflammation in a murine model of inflammatory bowel disease.
Anthoni C, Mennigen RB, Rijcken EJ, Laukötter MG, Spiegel HU, Senninger N, Schürmann G, Krieglstein CF. Anthoni C, et al. Int J Colorectal Dis. 2006 Jul;21(5):409-18. doi: 10.1007/s00384-005-0015-3. Epub 2005 Aug 9. Int J Colorectal Dis. 2006. PMID: 16088386
Clinical and histological activity of inflammation were assessed by the disease activity index and modified Dieleman score, respectively. STATISTICS: Kruskal-Wallis test was used, followed by Dunn's method. ...Adherent leucocyte levels were markedly lower (1.2+/-0.3 vs 23. …
Clinical and histological activity of inflammation were assessed by the disease activity index and modified Dieleman score, respectiv …
Detection of postpartum uterine activity with electrohysterography.
Thijssen KMJ, van den Broek MJM, Koenraads FA, Cantineau-Goedegebuure JI, Papatsonis DNM, van Willigen BG, Dieleman JP, van der Hout-van der Jagt MB, Westerhuis MEMH, Oei SG. Thijssen KMJ, et al. Eur J Obstet Gynecol Reprod Biol. 2023 Dec;291:23-28. doi: 10.1016/j.ejogrb.2023.10.005. Epub 2023 Oct 4. Eur J Obstet Gynecol Reprod Biol. 2023. PMID: 37806028 Free article.
Could electrohysterography be the solution for external uterine monitoring in obese women?
Vlemminx MWC, Thijssen KMJ, Bajlekov GI, Dieleman JP, Van Der Hout-Van Der Jagt MB, Oei SG. Vlemminx MWC, et al. J Perinatol. 2018 May;38(5):580-586. doi: 10.1038/s41372-018-0065-3. Epub 2018 Feb 21. J Perinatol. 2018. PMID: 29467514

In morbidly obese women, the median sensitivity was 87.2% (IQR 74-93) by electrohysterography and 45.0% (IQR 36-66) by external tocodynamometry (p < 0.001). The sensitivity of electrohysterography appeared to be non-influenced by obesity category (p = 0.279) and

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In morbidly obese women, the median sensitivity was 87.2% (IQR 74-93) by electrohysterography and 45.0% (IQR 36-66) by external tocodynamome …
Early Catheter Ablation Versus Initial Medical Therapy for Ventricular Tachycardia Storm.
Huang K, Bennett RG, Campbell T, Lee V, Turnbull S, Chik WWB, El-Sokkari I, Hallani H, Dieleman J, Kruit N, Eslick A, Priestley M, Burgess D, Thomas SP, Denniss AR, Chow CK, Kumar S. Huang K, et al. Circ Arrhythm Electrophysiol. 2022 Dec;15(12):e011129. doi: 10.1161/CIRCEP.122.011129. Epub 2022 Nov 18. Circ Arrhythm Electrophysiol. 2022. PMID: 36399370
Over a median follow-up of 702 days, patients who underwent initial CA compared with those treated with initial medical therapy had significantly less: (i) VA recurrence (43% versus 92%; P=0.002); (ii) VT storm recurrence (28% versus 73%; P<0.001); (iii) composit …
Over a median follow-up of 702 days, patients who underwent initial CA compared with those treated with initial medical therapy had signific …
Physical Training and Healthy Diet Improved Bowel Symptoms, Quality of Life, and Fatigue in Children With Inflammatory Bowel Disease.
Scheffers LE, Vos IK, Utens EMWJ, Dieleman GC, Walet S, Escher JC, van den Berg LEM; Rotterdam Exercise Team. Scheffers LE, et al. J Pediatr Gastroenterol Nutr. 2023 Aug 1;77(2):214-221. doi: 10.1097/MPG.0000000000003816. Epub 2023 May 3. J Pediatr Gastroenterol Nutr. 2023. PMID: 37134004 Free PMC article. Clinical Trial.
While medical treatment remained unchanged, Pediatric Crohn's Disease Activity Index decreased significantly versus the control period (15 [3-25] vs 2.5 [0-5], P = 0.012), and fecal calprotectin also decreased significantly but not versus the control period. ...
While medical treatment remained unchanged, Pediatric Crohn's Disease Activity Index decreased significantly versus the control period (15 [ …
112 results