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Page 1
Ezetimibe Added to Statin Therapy after Acute Coronary Syndromes.
Cannon CP, Blazing MA, Giugliano RP, McCagg A, White JA, Theroux P, Darius H, Lewis BS, Ophuis TO, Jukema JW, De Ferrari GM, Ruzyllo W, De Lucca P, Im K, Bohula EA, Reist C, Wiviott SD, Tershakovec AM, Musliner TA, Braunwald E, Califf RM; IMPROVE-IT Investigators. Cannon CP, et al. N Engl J Med. 2015 Jun 18;372(25):2387-97. doi: 10.1056/NEJMoa1410489. Epub 2015 Jun 3. N Engl J Med. 2015. PMID: 26039521 Free article. Clinical Trial.
RESULTS: The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simvastatin-ezetimibe group, as compared with 69.5 mg per deciliter (1.8 mmol per liter) in the simvastatin-monotherapy group (P<0.001) …
RESULTS: The median time-weighted average LDL cholesterol level during the study was 53.7 mg per deciliter (1.4 mmol per liter) in the simva …
Targeted Temperature Management for Cardiac Arrest with Nonshockable Rhythm.
Lascarrou JB, Merdji H, Le Gouge A, Colin G, Grillet G, Girardie P, Coupez E, Dequin PF, Cariou A, Boulain T, Brule N, Frat JP, Asfar P, Pichon N, Landais M, Plantefeve G, Quenot JP, Chakarian JC, Sirodot M, Legriel S, Letheulle J, Thevenin D, Desachy A, Delahaye A, Botoc V, Vimeux S, Martino F, Giraudeau B, Reignier J; CRICS-TRIGGERSEP Group. Lascarrou JB, et al. N Engl J Med. 2019 Dec 12;381(24):2327-2337. doi: 10.1056/NEJMoa1906661. Epub 2019 Oct 2. N Engl J Med. 2019. PMID: 31577396 Clinical Trial.
On day 90, a total of 29 of 284 patients (10.2%) in the hypothermia group were alive with a CPC score of 1 or 2, as compared with 17 of 297 (5.7%) in the normothermia group (difference, 4.5 percentage points; 95% confidence interval [CI], 0.1 to 8.9; P = 0.04). Mortality a …
On day 90, a total of 29 of 284 patients (10.2%) in the hypothermia group were alive with a CPC score of 1 or 2, as compared with 17 of 297 …
A gene-expression signature as a predictor of survival in breast cancer.
van de Vijver MJ, He YD, van't Veer LJ, Dai H, Hart AA, Voskuil DW, Schreiber GJ, Peterse JL, Roberts C, Marton MJ, Parrish M, Atsma D, Witteveen A, Glas A, Delahaye L, van der Velde T, Bartelink H, Rodenhuis S, Rutgers ET, Friend SH, Bernards R. van de Vijver MJ, et al. N Engl J Med. 2002 Dec 19;347(25):1999-2009. doi: 10.1056/NEJMoa021967. N Engl J Med. 2002. PMID: 12490681 Free article.
The estimated hazard ratio for distant metastases in the group with a poor-prognosis signature, as compared with the group with the good-prognosis signature, was 5.1 (95 percent confidence interval, 2.9 to 9.0; P<0.001). This ratio remained significant when the groups w …
The estimated hazard ratio for distant metastases in the group with a poor-prognosis signature, as compared with the group with the good-pro …
Risk stratification of patients with aortic stenosis.
Vahanian A, Otto CM. Vahanian A, et al. Eur Heart J. 2010 Feb;31(4):416-23. doi: 10.1093/eurheartj/ehp575. Epub 2010 Jan 4. Eur Heart J. 2010. PMID: 20047994 Review.
Aortic stenosis (AS) is now the most common indication for valve replacement in Europe and North America, with an ever increasing disease prevalence due to the ageing population (Iung B, Baron G, Butchart EG, Delahaye F, Gohlke-Barwolf C, Levang AW, Tornos P, Vanove …
Aortic stenosis (AS) is now the most common indication for valve replacement in Europe and North America, with an ever increasing disease pr …
CRAFTing a New Approach to Antiepileptic Drug Discovery.
Lyman KA, Chetkovich DM. Lyman KA, et al. Epilepsy Curr. 2019 May-Jun;19(3):182-183. doi: 10.1177/1535759719842148. Epub 2019 Apr 29. Epilepsy Curr. 2019. PMID: 31035818 Free PMC article.
Srivastava PK, van Eyll J, Godard P, Mazzuferi M, Delahaye-Duriez A, Steenwinckel JV, et al. ...
Srivastava PK, van Eyll J, Godard P, Mazzuferi M, Delahaye-Duriez A, Steenwinckel JV, et al. ...
Candida infective endocarditis.
Baddley JW, Benjamin DK Jr, Patel M, Miró J, Athan E, Barsic B, Bouza E, Clara L, Elliott T, Kanafani Z, Klein J, Lerakis S, Levine D, Spelman D, Rubinstein E, Tornos P, Morris AJ, Pappas P, Fowler VG Jr, Chu VH, Cabell C; International Collaboration on Endocarditis-Prospective Cohort Study Group (ICE-PCS). Baddley JW, et al. Eur J Clin Microbiol Infect Dis. 2008 Jul;27(7):519-29. doi: 10.1007/s10096-008-0466-x. Epub 2008 Feb 19. Eur J Clin Microbiol Infect Dis. 2008. PMID: 18283504 Free PMC article.

We noted that patients with Candida IE were more likely to have prosthetic valves (p < 0.001), short-term indwelling catheters (p < 0.0001), and have healthcare-associated infections (p < 0.001). The reasons for surgery differed between the two group

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We noted that patients with Candida IE were more likely to have prosthetic valves (p < 0.001), short-term indwelling catheters (

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Infective Endocarditis After Transcatheter Versus Surgical Aortic Valve Replacement.
Panagides V, Cuervo G, Llopis J, Abdel-Wahab M, Mangner N, Habib G, Regueiro A, Mestres CA, Tornos P, Durand E, Selton-Suty C, Ihlemann N, Bruun N, Urena M, Cecchi E, Thiele H, Durante-Mangoni E, Pellegrini C, Eltchaninoff H, Athan E, Søndergaard L, Linke A, Tattevin P, Del Val D, Quintana E, Chu V, Rodés-Cabau J, Miro JM; TAVI Infective Endocarditis International Registry and ICE Investigators. Panagides V, et al. Clin Infect Dis. 2024 Jan 25;78(1):179-187. doi: 10.1093/cid/ciad464. Clin Infect Dis. 2024. PMID: 37552784 Free article.

Patients with an SB had a higher rate of perivalvular extension (47.9% vs 27%; P < .001) and Staphylococcus aureus was less common in this group (13.4% vs 22%; P = .033). Despite a higher rate of surgery in patients with SB (44.4% vs 27.3%; P < .001), 1

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Patients with an SB had a higher rate of perivalvular extension (47.9% vs 27%; P < .001) and Staphylococcus aureus was less common

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Infective Endocarditis in Patients on Chronic Hemodialysis.
Pericàs JM, Llopis J, Jiménez-Exposito MJ, Kourany WM, Almirante B, Carosi G, Durante-Mangoni E, Fortes CQ, Giannitsioti E, Lerakis S, Montagna-Mella R, Ambrosioni J, Tan RS, Mestres CA, Wray D, Pachirat O, Moreno A, Chu VH, de Lazzari E, Fowler VG Jr, Miró JM; ICE Investigators. Pericàs JM, et al. J Am Coll Cardiol. 2021 Apr 6;77(13):1629-1640. doi: 10.1016/j.jacc.2021.02.014. J Am Coll Cardiol. 2021. PMID: 33795037 Free article.

Both in-hospital and 6-month mortality were significantly higher in HD versus non-HD-IE patients (30.4% vs. 17% and 39.8% vs. 20.7%, respectively; p < 0.001). Cardiac surgery was less frequently performed among HD patients (30.6% vs. 46.2%; p < 0.001), whereas

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Both in-hospital and 6-month mortality were significantly higher in HD versus non-HD-IE patients (30.4% vs. 17% and 39.8% vs. 20.7%, respect …
Natural history of severe mitral regurgitation.
Delahaye JP, Gare JP, Viguier E, Delahaye F, De Gevigney G, Milon H. Delahaye JP, et al. Eur Heart J. 1991 Jul;12 Suppl B:5-9. doi: 10.1093/eurheartj/12.suppl_b.5. Eur Heart J. 1991. PMID: 1936025 Review.
Baseline characteristics were similar in the two groups, except for aetiology (less dystrophic and more ischaemic MR in group 2), functional class (88.3% class III or IV in group 1 vs 48.1% in group 2; P = 0.001), pulmonary pressures (lower in group 2) and left ventricular …
Baseline characteristics were similar in the two groups, except for aetiology (less dystrophic and more ischaemic MR in group 2), functional …
Prognostic value of cardiovascular magnetic resonance T1 mapping and extracellular volume fraction in nonischemic dilated cardiomyopathy.
Cadour F, Quemeneur M, Biere L, Donal E, Bentatou Z, Eicher JC, Roubille F, Lalande A, Giorgi R, Rapacchi S, Cortaredona S, Tradi F, Bartoli A, Willoteaux S, Delahaye F, Biene SM, Mangin L, Ferrier N, Dacher JN, Bauer F, Leurent G, Lentz PA, Kovacsik H, Croisille P, Thuny F, Bernard M, Guye M, Furber A, Habib G, Jacquier A. Cadour F, et al. J Cardiovasc Magn Reson. 2023 Feb 6;25(1):7. doi: 10.1186/s12968-023-00919-y. J Cardiovasc Magn Reson. 2023. PMID: 36747201 Free PMC article.
RESULTS: Fifty-eight patients (26%) developed a MACE during follow-up, 42 patients (19%) with HF-related events and 16 patients (7%) arrhythmia-related events. T1 Z-score (p = 0.008) and global ECV (p = 0.001) were associated with HF-related events occurrence, in ad …
RESULTS: Fifty-eight patients (26%) developed a MACE during follow-up, 42 patients (19%) with HF-related events and 16 patients (7%) arrhyth …
73 results