Trastuzumab Emtansine Plus Non-Pegylated Liposomal Doxorubicin in HER2-Positive Metastatic Breast Cancer (Thelma): A Single-Arm, Multicenter, Phase Ib Trial.
López-Miranda E, Pérez-García JM, Di Cosimo S, Brain E, Ravnik M, Escrivá-de-Romaní S, Vidal M, Gligorov J, Borštnar S, Calabuig L, Sampayo-Cordero M, Malfettone A, Llombart-Cussac A, Suter TM, Cortés J.
López-Miranda E, et al.
Cancers (Basel). 2020 Nov 25;12(12):3509. doi: 10.3390/cancers12123509.
Cancers (Basel). 2020.
PMID: 33255658
Free PMC article.
Patients received a maximum of 6 cycles of NPLD intravenously (IV) at various dose levels (45, 50, and 60 mg/m(2)) in the "3 plus 3" dose-escalation part. During expansion, they received 60 mg/m(2) of NPLD every 3 weeks (Q3W) plus standard doses of T-DM1. The MTD wa …
Patients received a maximum of 6 cycles of NPLD intravenously (IV) at various dose levels (45, 50, and 60 mg/m(2)) in the "3 plus 3" …