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Page 1
Proteogenomic Landscape of Breast Cancer Tumorigenesis and Targeted Therapy.
Krug K, Jaehnig EJ, Satpathy S, Blumenberg L, Karpova A, Anurag M, Miles G, Mertins P, Geffen Y, Tang LC, Heiman DI, Cao S, Maruvka YE, Lei JT, Huang C, Kothadia RB, Colaprico A, Birger C, Wang J, Dou Y, Wen B, Shi Z, Liao Y, Wiznerowicz M, Wyczalkowski MA, Chen XS, Kennedy JJ, Paulovich AG, Thiagarajan M, Kinsinger CR, Hiltke T, Boja ES, Mesri M, Robles AI, Rodriguez H, Westbrook TF, Ding L, Getz G, Clauser KR, Fenyö D, Ruggles KV, Zhang B, Mani DR, Carr SA, Ellis MJ, Gillette MA; Clinical Proteomic Tumor Analysis Consortium. Krug K, et al. Cell. 2020 Nov 25;183(5):1436-1456.e31. doi: 10.1016/j.cell.2020.10.036. Epub 2020 Nov 18. Cell. 2020. PMID: 33212010 Free PMC article.
The Use of Rifaximin in the Prevention of Overt Hepatic Encephalopathy After Transjugular Intrahepatic Portosystemic Shunt : A Randomized Controlled Trial.
Bureau C, Thabut D, Jezequel C, Archambeaud I, D'Alteroche L, Dharancy S, Borentain P, Oberti F, Plessier A, De Ledinghen V, Ganne-Carrié N, Carbonell N, Rousseau V, Sommet A, Péron JM, Vinel JP. Bureau C, et al. Ann Intern Med. 2021 May;174(5):633-640. doi: 10.7326/M20-0202. Epub 2021 Feb 2. Ann Intern Med. 2021. PMID: 33524293 Clinical Trial.
Antihypertensive treatment changes and related clinical outcomes in older hospitalized patients.
Cicco S, D Abbondanza M, Proietti M, Zaccone V, Pes C, Caradio F, Mattioli M, Piano S, Marra AM, Nobili A, Mannucci PM, Pietrangelo A, Sesti G, Buzzetti E, Salzano A, Cimellaro A; Giovani Internisti Società Italiana di Medicina Interna (GIS-SIMI) and of the REPOSI Investigators. Cicco S, et al. Eur J Clin Invest. 2023 Apr;53(4):e13931. doi: 10.1111/eci.13931. Epub 2022 Dec 21. Eur J Clin Invest. 2023. PMID: 36453932
Integrating genetic variants into clinical models for hepatocellular carcinoma risk stratification in cirrhosis.
Nahon P, Bamba-Funck J, Layese R, Trépo E, Zucman-Rossi J, Cagnot C, Ganne-Carrié N, Chaffaut C, Guyot E, Ziol M, Sutton A, Audureau E; ANRS CO12 CirVir and CIRRAL groups. Nahon P, et al. J Hepatol. 2023 Mar;78(3):584-595. doi: 10.1016/j.jhep.2022.11.003. Epub 2022 Nov 22. J Hepatol. 2023. PMID: 36427656
The predictive ability of two clinical scores (a routine non-genetic model determined by multivariate analysis and the external aMAP score) with/without the GRS was evaluated by C-indices. The standardised net benefit was derived from decision curves. ...The clinical model …
The predictive ability of two clinical scores (a routine non-genetic model determined by multivariate analysis and the external aMAP score) …
Improved diagnostic accuracy of blood tests for severe fibrosis and cirrhosis in chronic hepatitis C.
Boursier J, Bacq Y, Halfon P, Leroy V, de Ledinghen V, de Muret A, Bourlière M, Sturm N, Foucher J, Oberti F, Rousselet MC, Calès P. Boursier J, et al. Eur J Gastroenterol Hepatol. 2009 Jan;21(1):28-38. doi: 10.1097/MEG.0b013e32830cebd7. Eur J Gastroenterol Hepatol. 2009. PMID: 19060630 Review.
METHODS: The accuracy for severe fibrosis or cirrhosis of four blood tests was evaluated based on Metavir staging in 1056 patients with chronic hepatitis C recruited in five independent hospitals. RESULTS: Using original scores, an original diagnostic target (significant f …
METHODS: The accuracy for severe fibrosis or cirrhosis of four blood tests was evaluated based on Metavir staging in 1056 patients with chro …
Cu(II) Binding Increases the Soluble Toxicity of Amyloidogenic Light Chains.
Russo R, Romeo M, Schulte T, Maritan M, Oberti L, Barzago MM, Barbiroli A, Pappone C, Anastasia L, Palladini G, Diomede L, Ricagno S. Russo R, et al. Int J Mol Sci. 2022 Jan 16;23(2):950. doi: 10.3390/ijms23020950. Int J Mol Sci. 2022. PMID: 35055136 Free PMC article.
Organ damage is caused not only by the accumulation of bulky amyloid deposits, but extensive clinical data indicate that circulating soluble LCs also exert cardiotoxic effects. The nematode C. elegans has been validated to recapitulate LC soluble toxicity in vivo, and in s …
Organ damage is caused not only by the accumulation of bulky amyloid deposits, but extensive clinical data indicate that circulating soluble …
Dynamic personalized prediction of the individual liver-related risk after sustained viral response in HCV patients.
Moreau C, Roux M, Riou J, Canivet CM, Audureau E, Lusivika-Nzinga C, Nahon P, Carrat F, Boursier J; ANRS CO12 CirVir group and the ANRS CO22 HEPATHER group. Moreau C, et al. J Viral Hepat. 2023 Jun;30(6):567-577. doi: 10.1111/jvh.13830. Epub 2023 Mar 31. J Viral Hepat. 2023. PMID: 36891763
Sustained viral response (SVR) significantly improves the prognosis in patients with hepatitis C virus (HCV) chronic infection but does not totally alleviate the risk of liver-related complications (LRC). ...
Sustained viral response (SVR) significantly improves the prognosis in patients with hepatitis C virus (HCV) chronic infection but do …
Inherent Biophysical Properties Modulate the Toxicity of Soluble Amyloidogenic Light Chains.
Maritan M, Romeo M, Oberti L, Sormanni P, Tasaki M, Russo R, Ambrosetti A, Motta P, Rognoni P, Mazzini G, Barbiroli A, Palladini G, Vendruscolo M, Diomede L, Bolognesi M, Merlini G, Lavatelli F, Ricagno S. Maritan M, et al. J Mol Biol. 2020 Feb 14;432(4):845-860. doi: 10.1016/j.jmb.2019.12.015. Epub 2019 Dec 24. J Mol Biol. 2020. PMID: 31874151 Free article.
The resulting mutant (mH6) is less toxic than its parent H6 to human cardiac fibroblasts and C. elegans. The high sequence and structural similarity, together with the different toxicity, make H6 and its non-toxic designed variant mH6 a test case to shed light on the molec …
The resulting mutant (mH6) is less toxic than its parent H6 to human cardiac fibroblasts and C. elegans. The high sequence and struct …
Phytotoxic withanolides from Jaborosa rotacea.
Nicotra VE, Ramacciotti NS, Gil RR, Oberti JC, Feresin GE, Guerrero CA, Baggio RF, Garland MT, Burton G. Nicotra VE, et al. J Nat Prod. 2006 May;69(5):783-9. doi: 10.1021/np0600090. J Nat Prod. 2006. PMID: 16724841
Twelve new withanolides were isolated from the aerial part of Jaborosa rotacea: five had a spiranoid delta-lactone (1-5); one contained a 26,12-delta-lactone and a C-12-C-23 bond (6); five corresponded to trechonolide-type withanolides with configuration at C …
Twelve new withanolides were isolated from the aerial part of Jaborosa rotacea: five had a spiranoid delta-lactone (1-5); one contained a 26 …
15,21-Cyclowithanolides from Jaborosa bergii.
Nicotra VE, Gil RR, Vaccarini C, Oberti JC, Burton G. Nicotra VE, et al. J Nat Prod. 2003 Nov;66(11):1471-5. doi: 10.1021/np030248c. J Nat Prod. 2003. PMID: 14640521
Five of the new compounds presented a novel norbornane-type structure in ring D of the steroid nucleus (1-5), resulting from a carbon-carbon bond between C-15 and C-21. The sixth withanolide isolated was the 5alpha-chloro-6beta-hydroxy analogue (6) of 2,3-dehydrojab …
Five of the new compounds presented a novel norbornane-type structure in ring D of the steroid nucleus (1-5), resulting from a carbon-carbon …
29 results