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Neuroimmunomodulatory Properties of Flavonoids and Derivates: A Potential Action as Adjuvants for the Treatment of Glioblastoma.
do Nascimento RP, Dos Santos BL, Amparo JAO, Soares JRP, da Silva KC, Santana MR, Almeida ÁMAN, da Silva VDA, Costa MFD, Ulrich H, Moura-Neto V, Lopes GPF, Costa SL. do Nascimento RP, et al. Among authors: amparo jao. Pharmaceutics. 2022 Jan 4;14(1):116. doi: 10.3390/pharmaceutics14010116. Pharmaceutics. 2022. PMID: 35057010 Free PMC article. Review.
The flavonoid rutin and its aglycone quercetin modulate the microglia inflammatory profile improving antiglioma activity.
da Silva AB, Cerqueira Coelho PL, das Neves Oliveira M, Oliveira JL, Oliveira Amparo JA, da Silva KC, Soares JRP, Pitanga BPS, Dos Santos Souza C, de Faria Lopes GP, da Silva VDA, de Fátima Dias Costa M, Junier MP, Chneiweiss H, Moura-Neto V, Costa SL. da Silva AB, et al. Among authors: oliveira amparo ja. Brain Behav Immun. 2020 Mar;85:170-185. doi: 10.1016/j.bbi.2019.05.003. Epub 2019 May 3. Brain Behav Immun. 2020. PMID: 31059805
The flavonoid rutin modulates microglial/macrophage activation to a CD150/CD206 M2 phenotype.
Bispo da Silva A, Cerqueira Coelho PL, Alves Oliveira Amparo J, Alves de Almeida Carneiro MM, Pereira Borges JM, Dos Santos Souza C, Dias Costa MF, Mecha M, Guaza Rodriguez C, Amaral da Silva VD, Lima Costa S. Bispo da Silva A, et al. Among authors: alves oliveira amparo j. Chem Biol Interact. 2017 Aug 25;274:89-99. doi: 10.1016/j.cbi.2017.07.004. Epub 2017 Jul 8. Chem Biol Interact. 2017. PMID: 28693884