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The triple function of the capsaicin-sensitive sensory neurons: In memoriam Janos Szolcsanyi.
Pintér E, Helyes Z, Szőke É, Bölcskei K, Kecskés A, Pethő G. Pintér E, et al. Temperature (Austin). 2022 Nov 21;10(1):13-34. doi: 10.1080/23328940.2022.2147388. eCollection 2023. Temperature (Austin). 2022. PMID: 38059854 Free PMC article. Review.
This paper is dedicated to the memory of Janos Szolcsanyi (1938-2018), an outstanding Hungarian scientist. ...He discovered a new neuroregulatory system without sensory efferent reflex and investigated its pharmacology. The authors of this review are his former Ph.D
This paper is dedicated to the memory of Janos Szolcsanyi (1938-2018), an outstanding Hungarian scientist. ...He discovered a new neu …
Small molecule somatostatin receptor subtype 4 (sst4) agonists are novel anti-inflammatory and analgesic drug candidates.
Szőke É, Bálint M, Hetényi C, Markovics A, Elekes K, Pozsgai G, Szűts T, Kéri G, Őrfi L, Sándor Z, Szolcsányi J, Pintér E, Helyes Z. Szőke É, et al. Neuropharmacology. 2020 Nov 1;178:108198. doi: 10.1016/j.neuropharm.2020.108198. Epub 2020 Jul 30. Neuropharmacology. 2020. PMID: 32739276
We modeled the sst(4) receptor structure, described its agonist binding properties, and characterized the binding of our novel small molecule sst(4) agonists (4-phenetylamino-7H-pyrrolo[2,3-d]pyrimidine derivatives) using an in silico platform. In addition to the in silico …
We modeled the sst(4) receptor structure, described its agonist binding properties, and characterized the binding of our novel small molecul …
Transient receptor potential channel ankyrin-1 is not a cold sensor for autonomic thermoregulation in rodents.
de Oliveira C, Garami A, Lehto SG, Pakai E, Tekus V, Pohoczky K, Youngblood BD, Wang W, Kort ME, Kym PR, Pinter E, Gavva NR, Romanovsky AA. de Oliveira C, et al. J Neurosci. 2014 Mar 26;34(13):4445-52. doi: 10.1523/JNEUROSCI.5387-13.2014. J Neurosci. 2014. PMID: 24671991 Free PMC article.
In rats, the effects of pharmacological blockade were studied by using two chemically unrelated TRPA1 antagonists: the highly potent and selective compound A967079, which had been characterized earlier, and the relatively new compound 43 ((4R)-1,2,3,4-tetrahydro-4-[3-(3-methoxypr …
In rats, the effects of pharmacological blockade were studied by using two chemically unrelated TRPA1 antagonists: the highly potent and sel …
In Silico, In Vitro and In Vivo Pharmacodynamic Characterization of Novel Analgesic Drug Candidate Somatostatin SST4 Receptor Agonists.
Kántás B, Szőke É, Börzsei R, Bánhegyi P, Asghar J, Hudhud L, Steib A, Hunyady Á, Horváth Á, Kecskés A, Borbély É, Hetényi C, Pethő G, Pintér E, Helyes Z. Kántás B, et al. Front Pharmacol. 2021 Jan 27;11:601887. doi: 10.3389/fphar.2020.601887. eCollection 2020. Front Pharmacol. 2021. PMID: 33815096 Free PMC article.
Analgesic effect of TT-232, a heptapeptide somatostatin analogue, in acute pain models of the rat and the mouse and in streptozotocin-induced diabetic mechanical allodynia.
Szolcsányi J, Bölcskei K, Szabó A, Pintér E, Petho G, Elekes K, Börzsei R, Almási R, Szuts T, Kéri G, Helyes Z. Szolcsányi J, et al. Eur J Pharmacol. 2004 Sep 13;498(1-3):103-9. doi: 10.1016/j.ejphar.2004.07.085. Eur J Pharmacol. 2004. PMID: 15363982
Somatostatin released from capsaicin-sensitive sensory nerves exerts systemic anti-inflammatory and antinociceptive actions. TT-232 is a stable, peripherally acting heptapeptide (D-Phe-Cys-Tyr-D-Trp-Lys-Cys-Thr-NH2) somatostatin analogue with highest binding affinit …
Somatostatin released from capsaicin-sensitive sensory nerves exerts systemic anti-inflammatory and antinociceptive actions. TT-232 is a sta …