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Squamous differentiation requires G2/mitosis slippage to avoid apoptosis.
Sanz-Gómez N, de Pedro I, Ortigosa B, Santamaría D, Malumbres M, de Cárcer G, Gandarillas A. Sanz-Gómez N, et al. Among authors: de pedro i. Cell Death Differ. 2020 Aug;27(8):2451-2467. doi: 10.1038/s41418-020-0515-2. Epub 2020 Feb 20. Cell Death Differ. 2020. PMID: 32080348 Free PMC article.
Inefficient differentiation response to cell cycle stress leads to genomic instability and malignant progression of squamous carcinoma cells.
Alonso-Lecue P, de Pedro I, Coulon V, Molinuevo R, Lorz C, Segrelles C, Ceballos L, López-Aventín D, García-Valtuille A, Bernal JM, Mazorra F, Pujol RM, Paramio J, Ramón Sanz J, Freije A, Toll A, Gandarillas A. Alonso-Lecue P, et al. Among authors: de pedro i. Cell Death Dis. 2017 Jun 29;8(6):e2901. doi: 10.1038/cddis.2017.259. Cell Death Dis. 2017. PMID: 28661481 Free PMC article.