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Page 1
Oncogenic Gαq activates RhoJ through PDZ-RhoGEF.
Cervantes-Villagrana RD, Color-Aparicio VM, Castillo-Kauil A, García-Jiménez I, Beltrán-Navarro YM, Reyes-Cruz G, Vázquez-Prado J. Cervantes-Villagrana RD, et al. Among authors: garcia jimenez i. Int J Mol Sci. 2023 Oct 29;24(21):15734. doi: 10.3390/ijms242115734. Int J Mol Sci. 2023. PMID: 37958718 Free PMC article.
Gαs directly drives PDZ-RhoGEF signaling to Cdc42.
Castillo-Kauil A, García-Jiménez I, Cervantes-Villagrana RD, Adame-García SR, Beltrán-Navarro YM, Gutkind JS, Reyes-Cruz G, Vázquez-Prado J. Castillo-Kauil A, et al. Among authors: garcia jimenez i. J Biol Chem. 2020 Dec 11;295(50):16920-16928. doi: 10.1074/jbc.AC120.015204. Epub 2020 Oct 6. J Biol Chem. 2020. PMID: 33023908 Free PMC article.
Gβγ recruits and activates P-Rex1 via two independent binding interfaces.
Cervantes-Villagrana RD, Beltrán-Navarro YM, García-Jiménez I, Adame-García SR, Olguín-Olguín A, Reyes-Cruz G, Vázquez-Prado J. Cervantes-Villagrana RD, et al. Among authors: garcia jimenez i. Biochem Biophys Res Commun. 2021 Feb 5;539:20-27. doi: 10.1016/j.bbrc.2020.12.089. Epub 2021 Jan 4. Biochem Biophys Res Commun. 2021. PMID: 33412417
Calcium sensing receptor stimulates breast cancer cell migration via the Gβγ-AKT-mTORC2 signaling pathway.
Orduña-Castillo LB, Del-Río-Robles JE, García-Jiménez I, Zavala-Barrera C, Beltrán-Navarro YM, Hidalgo-Moyle JJ, Ramírez-Rangel I, Hernández-Bedolla MA, Reyes-Ibarra AP, Valadez-Sánchez M, Vázquez-Prado J, Reyes-Cruz G. Orduña-Castillo LB, et al. Among authors: garcia jimenez i. J Cell Commun Signal. 2022 Jun;16(2):239-252. doi: 10.1007/s12079-021-00662-y. Epub 2021 Dec 1. J Cell Commun Signal. 2022. PMID: 34854057 Free PMC article.
The calcium sensing receptor (CaSR) promotes Rab27B expression and activity to control secretion in breast cancer cells.
Zavala-Barrera C, Del-Río-Robles JE, García-Jiménez I, Egusquiza-Alvarez CA, Hernández-Maldonado JP, Vázquez-Prado J, Reyes-Cruz G. Zavala-Barrera C, et al. Among authors: garcia jimenez i. Biochim Biophys Acta Mol Cell Res. 2021 Jun;1868(7):119026. doi: 10.1016/j.bbamcr.2021.119026. Epub 2021 Apr 15. Biochim Biophys Acta Mol Cell Res. 2021. PMID: 33845096 Free article.
Endothelial cell sprouting driven by RhoJ directly activated by a membrane-anchored Intersectin 1 (ITSN1) RhoGEF module.
Color-Aparicio VM, Cervantes-Villagrana RD, García-Jiménez I, Beltrán-Navarro YM, Castillo-Kauil A, Escobar-Islas E, Reyes-Cruz G, Vázquez-Prado J. Color-Aparicio VM, et al. Among authors: garcia jimenez i. Biochem Biophys Res Commun. 2020 Mar 26;524(1):109-116. doi: 10.1016/j.bbrc.2020.01.068. Epub 2020 Jan 21. Biochem Biophys Res Commun. 2020. PMID: 31980169
Gβγ signaling to the chemotactic effector P-REX1 and mammalian cell migration is directly regulated by Gαq and Gα13 proteins.
Cervantes-Villagrana RD, Adame-García SR, García-Jiménez I, Color-Aparicio VM, Beltrán-Navarro YM, König GM, Kostenis E, Reyes-Cruz G, Gutkind JS, Vázquez-Prado J. Cervantes-Villagrana RD, et al. Among authors: garcia jimenez i. J Biol Chem. 2019 Jan 11;294(2):531-546. doi: 10.1074/jbc.RA118.006254. Epub 2018 Nov 16. J Biol Chem. 2019. PMID: 30446620 Free PMC article.