The role of tyrosine phosphorylation in regulation of signal transduction pathways in unicellular eukaryotes

Irina V Schemarova

The role of tyrosine phosphorylation in regulation of signal transduction pathways in unicellular eukaryotes

Curr Issues Mol Biol. 2006 Jan;8(1):27-49.

Author

Irina V Schemarova¹

Affiliation

¹ Sechenov Institute of Evolutionary Physiology and Biochemistry, Russian Academy of Sciences, St. Petersburg 194223, Russia. Irina@lis.mail.iephb.ru

PMID: 16450884

Abstract

The review summarizes for the first time the current concepts of the role of tyrosine phosphorylation in regulation of signal transduction pathways in unicellular eukaryotes. Evolutionary concepts are developed about the origin of protein tyrosine kinases (PTK)-signaling.

Publication types

Review

MeSH terms

Animals
Eukaryotic Cells / metabolism*
Growth Substances / physiology*
Models, Biological
Phosphorylation
Phosphotyrosine / analogs & derivatives
Phosphotyrosine / metabolism*
Protein Kinases / metabolism
Protein Kinases / physiology*
STAT Transcription Factors / metabolism
Signal Transduction
Tyrosine / metabolism*
ras Proteins / physiology

Substances

Growth Substances
STAT Transcription Factors
Phosphotyrosine
Tyrosine
Protein Kinases
ras Proteins