Light distribution in fat cell layers at physiological temperatures

Irina Yu Yanina; Polina A Dyachenko; Arkady S Abdurashitov; Alexander S Shalin; Igor V Minin; Oleg V Minin; Andrey D Bulygin; Denis A Vrazhnov; Yury V Kistenev; Valery V Tuchin

doi:10.1038/s41598-022-25012-9

Light distribution in fat cell layers at physiological temperatures

Sci Rep. 2023 Jan 19;13(1):1073. doi: 10.1038/s41598-022-25012-9.

Authors

Irina Yu Yanina^{1

2}, Polina A Dyachenko^{3

4}, Arkady S Abdurashitov⁵, Alexander S Shalin^{6

7

8}, Igor V Minin^{9

10}, Oleg V Minin^{9

10}, Andrey D Bulygin^{4

11}, Denis A Vrazhnov^{4

12}, Yury V Kistenev^{4

12}, Valery V Tuchin^{3

4

13

14}

Affiliations

¹ Science Medical Center, Saratov State University, 83 Astrakhanskaya Str., Saratov, Russia, 410012. irina-yanina@list.ru.
² Laboratory of Laser Molecular Imaging and Machine Learning, Tomsk State University, 36 Lenin's Av., Tomsk, Russia, 634050. irina-yanina@list.ru.
³ Science Medical Center, Saratov State University, 83 Astrakhanskaya Str., Saratov, Russia, 410012.
⁴ Laboratory of Laser Molecular Imaging and Machine Learning, Tomsk State University, 36 Lenin's Av., Tomsk, Russia, 634050.
⁵ Center for Neurobiology and Brain Restoration, Skolkovo Institute of Science and Technology, 3Nobelya Str., Moscow, Russia, 121205.
⁶ Center for Photonics and 2D Materials, Moscow Institute of Physics and Technology, Dolgoprudny, 141700, Russia.
⁷ Institute of Telecommunications, Riga Technical University, 12 Azenes str., LV-1658, Riga, Latvia.
⁸ Laboratory of Fiber Optics and Optical Measurements UB-1, Kotel'nikov Institute of Radio Engineering and Electronics of Russian Academy of Sciences (Ulyanovsk Branch), 48 Goncharova Str., Ulyanovsk, Russia, 432011.
⁹ School of Nondestructive Testing, Tomsk Polytechnic University, 30 Lenin Av., Tomsk, Russia, 634050.
¹⁰ Institute for Strategic Studies, Siberian State University of Geosystems and Technologies, 10 Plahotnogo Str., Novosibirsk, Russia, 630108.
¹¹ Laboratory of Nonlinear Optical Interactions, V.E. Zuev Institute of Atmospheric Optics of Siberian Branch of the Russian Academy of Sciences, 1 Academician Zuev Sq., Tomsk, Russia, 634055.
¹² Laboratory for Remote Sensing of the Environment, V.E. Zuev Institute of Atmospheric Optics of Siberian Branch of the Russian Academy of Sciences, 1 Academician Zuev Sq., Tomsk, Russia, 634055.
¹³ Laboratory of Laser Diagnostics of Technical and Living Systems, Institute of Precision Mechanics and Control, FRC "Saratov Scientific Centre of the Russian Academy of Sciences", 24 Rabochaya Str., Saratov, Russia, 410028.
¹⁴ A.N. Bach Institute of Biochemistry, FRC "Fundamentals of Biotechnology", 33-2, Leninsky Av., Moscow, Russia, 119991.

Abstract

Adipose tissue (AT) optical properties for physiological temperatures and in vivo conditions are still insufficiently studied. The AT is composed mainly of packed cells close to spherical shape. It is a possible reason that AT demonstrates a very complicated spatial structure of reflected or transmitted light. It was shown with a cellular tissue phantom, is split into a fan of narrow tracks, originating from the insertion point and representing filament-like light distribution. The development of suitable approaches for describing light propagation in a AT is urgently needed. A mathematical model of the propagation of light through the layers of fat cells is proposed. It has been shown that the sharp local focusing of optical radiation (light localized near the shadow surface of the cells) and its cleavage by coupling whispering gallery modes depends on the optical thickness of the cell layer. The optical coherence tomography numerical simulation and experimental studies results demonstrate the importance of sharp local focusing in AT for understanding its optical properties for physiological conditions and at AT heating.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Adipocytes*
Computer Simulation
Models, Theoretical*
Scattering, Radiation
Temperature