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No association between initiation of phosphodiesterase-5 inhibitors and risk of incident Alzheimer's disease and related dementia: results from the Drug Repurposing for Effective Alzheimer's Medicines study.
Desai RJ, Mahesri M, Lee SB, Varma VR, Loeffler T, Schilcher I, Gerhard T, Segal JB, Ritchey ME, Horton DB, Kim SC, Schneeweiss S, Thambisetty M. Desai RJ, et al. Among authors: schilcher i. Brain Commun. 2022 Oct 4;4(5):fcac247. doi: 10.1093/braincomms/fcac247. eCollection 2022. Brain Commun. 2022. PMID: 36330433 Free PMC article.
Hydroxychloroquine lowers Alzheimer's disease and related dementias risk and rescues molecular phenotypes related to Alzheimer's disease.
Varma VR, Desai RJ, Navakkode S, Wong LW, Anerillas C, Loeffler T, Schilcher I, Mahesri M, Chin K, Horton DB, Kim SC, Gerhard T, Segal JB, Schneeweiss S, Gorospe M, Sajikumar S, Thambisetty M. Varma VR, et al. Among authors: schilcher i. Mol Psychiatry. 2023 Mar;28(3):1312-1326. doi: 10.1038/s41380-022-01912-0. Epub 2022 Dec 28. Mol Psychiatry. 2023. PMID: 36577843 Free PMC article.
MicroRNA-142-3p improves vascular relaxation in uremia.
Kétszeri M, Kirsch A, Frauscher B, Moschovaki-Filippidou F, Mooslechner AA, Kirsch AH, Schabhuettl C, Aringer I, Artinger K, Pregartner G, Ekart R, Breznik S, Hojs R, Goessler W, Schilcher I, Müller H, Obermayer-Pietsch B, Frank S, Rosenkranz AR, Eller P, Eller K. Kétszeri M, et al. Among authors: schilcher i. Atherosclerosis. 2019 Jan;280:28-36. doi: 10.1016/j.atherosclerosis.2018.11.024. Epub 2018 Nov 10. Atherosclerosis. 2019. PMID: 30453118 Free PMC article.
Astaxanthin enhances autophagy, amyloid beta clearance and exerts anti-inflammatory effects in in vitro models of Alzheimer's disease-related blood brain barrier dysfunction and inflammation.
Babalola JA, Lang M, George M, Stracke A, Tam-Amersdorfer C, Itxaso I, Lucija D, Tadic J, Schilcher I, Loeffler T, Flunkert S, Prokesch M, Leitinger G, Lass A, Hutter-Paier B, Panzenboeck U, Hoefler G. Babalola JA, et al. Among authors: schilcher i. Brain Res. 2023 Nov 15;1819:148518. doi: 10.1016/j.brainres.2023.148518. Epub 2023 Aug 12. Brain Res. 2023. PMID: 37579986 Free article.
Endothelial lipase increases antioxidative capacity of high-density lipoprotein.
Schilcher I, Ledinski G, Radulović S, Hallström S, Eichmann T, Madl T, Zhang F, Leitinger G, Kolb-Lenz D, Darnhofer B, Birner-Gruenberger R, Wadsack C, Kratky D, Marsche G, Frank S, Cvirn G. Schilcher I, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2019 Oct;1864(10):1363-1374. doi: 10.1016/j.bbalip.2019.06.011. Epub 2019 Jun 17. Biochim Biophys Acta Mol Cell Biol Lipids. 2019. PMID: 31220617 Free PMC article.
Endothelial lipase increases eNOS activating capacity of high-density lipoprotein.
Radulović S, Gottschalk B, Hörl G, Zardoya-Laguardia P, Schilcher I, Hallström S, Vujić N, Schmidt K, Trieb M, Graier WF, Malli R, Kratky D, Marsche G, Frank S. Radulović S, et al. Among authors: schilcher i. Biochim Biophys Acta Mol Cell Biol Lipids. 2020 Apr;1865(4):158612. doi: 10.1016/j.bbalip.2020.158612. Epub 2020 Jan 7. Biochim Biophys Acta Mol Cell Biol Lipids. 2020. PMID: 31923467 Free PMC article.
Endothelial Lipase Modulates Paraoxonase 1 Content and Arylesterase Activity of HDL.
Schilcher I, Stadler JT, Lechleitner M, Hrzenjak A, Berghold A, Pregartner G, Lhomme M, Holzer M, Korbelius M, Reichmann F, Springer A, Wadsack C, Madl T, Kratky D, Kontush A, Marsche G, Frank S. Schilcher I, et al. Int J Mol Sci. 2021 Jan 13;22(2):719. doi: 10.3390/ijms22020719. Int J Mol Sci. 2021. PMID: 33450841 Free PMC article.
A brain proteomic signature of incipient Alzheimer's disease in young APOE ε4 carriers identifies novel drug targets.
Roberts JA, Varma VR, An Y, Varma S, Candia J, Fantoni G, Tiwari V, Anerillas C, Williamson A, Saito A, Loeffler T, Schilcher I, Moaddel R, Khadeer M, Lovett J, Tanaka T, Pletnikova O, Troncoso JC, Bennett DA, Albert MS, Yu K, Niu M, Haroutunian V, Zhang B, Peng J, Croteau DL, Resnick SM, Gorospe M, Bohr VA, Ferrucci L, Thambisetty M. Roberts JA, et al. Among authors: schilcher i. Sci Adv. 2021 Nov 12;7(46):eabi8178. doi: 10.1126/sciadv.abi8178. Epub 2021 Nov 10. Sci Adv. 2021. PMID: 34757788 Free PMC article.
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