In this paper, the complex 3D virtual model of the prosthetic knee is obtained using embedded applications: DesignModeler and SpaceClaim under ANSYS Workbench 14.5 software package. A number of six cases of prosthetic knee joint assembly, depending on the malalignment angle, are developed. Stress maps and the values of the maximum von Mises stress on the three prosthesis components: polyethylene insert, tibial component and femoral component, for all studied prosthetic knee assemblies were obtained. The results show that as the malalignment angle increases, the values of von Mises stresses increase in all prosthesis components. The parameterized virtual models of the knee prosthesis components allow different changes in shape or dimensions, which can lead to the optimization of the implant and to the improvement of the prosthetic knee biomechanics.