A novel class of ion displacement ligands as antagonists of the alphaIIbbeta3 receptor that limit conformational reorganization of the receptor.
Jiang JK, McCoy JG, Shen M, LeClair CA, Huang W, Negri A, Li J, Blue R, Harrington AW, Naini S, David G 3rd, Choi WS, Volpi E, Fernandez J, Babayeva M, Nedelman MA, Filizola M, Coller BS, Thomas CJ.
Jiang JK, et al. Among authors: negri a.
Bioorg Med Chem Lett. 2014 Feb 15;24(4):1148-53. doi: 10.1016/j.bmcl.2013.12.122. Epub 2014 Jan 8.
Bioorg Med Chem Lett. 2014.
PMID: 24461295
Free PMC article.
A collection of alphaIIbbeta3 integrin receptor antagonists possessing a unique MIDAS metal ion displacement mechanism of action is presented. Insight into these agents' structure-activity relationships, binding modality, and pharmacokinetic and pharmacodynamic profiles hi …
A collection of alphaIIbbeta3 integrin receptor antagonists possessing a unique MIDAS metal ion displacement mechanism of action is p …