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Long-term mildronate treatment increased Proteobacteria level in gut microbiome, and caused behavioral deviations and transcriptome change in liver, heart and brain of healthy mice.
Gureev AP, Shaforostova EA, Vitkalova IY, Sadovnikova IS, Kalinina YI, Cherednichenko VR, Reznikova KA, Valuyskikh VV, Popov VN. Gureev AP, et al. Toxicol Appl Pharmacol. 2020 Jul 1;398:115031. doi: 10.1016/j.taap.2020.115031. Epub 2020 May 8. Toxicol Appl Pharmacol. 2020. PMID: 32389661