Synthesis of some novel 11b-substituted pyrimido[6,1-a]-isoquinoline derivatives

Plamen A Angelov; Iliyan I Ivanov; Atanas P Venkov

doi:10.3390/90800694

Synthesis of some novel 11b-substituted pyrimido[6,1-a]-isoquinoline derivatives

Molecules. 2004 Jul 31;9(8):694-704. doi: 10.3390/90800694.

Authors

Plamen A Angelov¹, Iliyan I Ivanov, Atanas P Venkov

Affiliation

¹ Department of Organic Chemistry, University of Plovdiv, 24 Tsar Asen str., 4000 Plovdiv, Bulgaria. angelov@argon.acad.bg

Abstract

A series of novel 11b-substituted 1,6,7,11b-tetrahydropyrimido[6,1-a]- isoquinoline-2,4-diones and 4-thioxo-1,3,4,6,7,11b-hexahydropyrimido[6,1-a]isoquinolin-2- ones were synthesized, utilizing two alternative strategies for ring closure of tetrahydroisoquinoline intermediates obtained from N-phenethyl enaminones.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Algorithms
Magnetic Resonance Spectroscopy
Models, Chemical
Protons
Pyrimidines / chemical synthesis
Pyrimidines / chemistry*
Tetrahydroisoquinolines / chemical synthesis*
Tetrahydroisoquinolines / chemistry

Substances

Protons
Pyrimidines
Tetrahydroisoquinolines