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Page 1
Proton bridging in the interactions of thrombin with hirudin and its mimics.
Biochemistry. 2013 Apr 9;52(14):2472-81. doi: 10.1021/bi301625a. Epub 2013 Apr 1.
Biochemistry. 2013.
PMID: 23517305
Free PMC article.
Proton Bridging in Catalysis by and Inhibition of Serine Proteases of the Blood Cascade System.
Kovach IM.
Kovach IM.
Life (Basel). 2021 Apr 27;11(5):396. doi: 10.3390/life11050396.
Life (Basel). 2021.
PMID: 33925363
Free PMC article.
Review.
Item in Clipboard
Full and partial deuterium solvent isotope effect studies of alpha-thrombin-catalyzed reactions of natural substrates.
Zhang D, Kovach IM.
Zhang D, et al. Among authors: kovach im.
J Am Chem Soc. 2005 Mar 23;127(11):3760-6. doi: 10.1021/ja043258o.
J Am Chem Soc. 2005.
PMID: 15771510
Item in Clipboard
Proton bridging in the interactions of thrombin with small inhibitors.
Kovach IM, Kelley P, Eddy C, Jordan F, Baykal A.
Kovach IM, et al.
Biochemistry. 2009 Aug 4;48(30):7296-304. doi: 10.1021/bi900098s.
Biochemistry. 2009.
PMID: 19530705
Free PMC article.
Item in Clipboard
Proton inventory studies of alpha-thrombin-catalyzed reactions of substrates with selected P and P' sites.
Enyedy EJ, Kovach IM.
Enyedy EJ, et al. Among authors: kovach im.
J Am Chem Soc. 2004 May 19;126(19):6017-24. doi: 10.1021/ja0320166.
J Am Chem Soc. 2004.
PMID: 15137766
Item in Clipboard
Locating the rate-determining step(s) for three-step hydrolase-catalyzed reactions with DYNAFIT.
Zhang D, Kovach IM, Sheehy JP.
Zhang D, et al. Among authors: kovach im.
Biochim Biophys Acta. 2008 May;1784(5):827-33. doi: 10.1016/j.bbapap.2008.02.004. Epub 2008 Mar 10.
Biochim Biophys Acta. 2008.
PMID: 18342021
Free PMC article.
Item in Clipboard
Deuterium solvent isotope effect and proton-inventory studies of factor Xa-catalyzed reactions.
Zhang D, Kovach IM.
Zhang D, et al. Among authors: kovach im.
Biochemistry. 2006 Nov 28;45(47):14175-82. doi: 10.1021/bi061218m.
Biochemistry. 2006.
PMID: 17115712
Free PMC article.
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