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Mirikizumab as Induction and Maintenance Therapy for Ulcerative Colitis.
D'Haens G, Dubinsky M, Kobayashi T, Irving PM, Howaldt S, Pokrotnieks J, Krueger K, Laskowski J, Li X, Lissoos T, Milata J, Morris N, Arora V, Milch C, Sandborn W, Sands BE; LUCENT Study Group. D'Haens G, et al. N Engl J Med. 2023 Jun 29;388(26):2444-2455. doi: 10.1056/NEJMoa2207940. N Engl J Med. 2023. PMID: 37379135 Clinical Trial.
Ligand-induced formation of transient dimers of mammalian 12/15-lipoxygenase: a key to allosteric behavior of this class of enzymes?
Ivanov I, Shang W, Toledo L, Masgrau L, Svergun DI, Stehling S, Gómez H, Di Venere A, Mei G, Lluch JM, Skrzypczak-Jankun E, González-Lafont A, Kühn H. Ivanov I, et al. Proteins. 2012 Mar;80(3):703-12. doi: 10.1002/prot.23227. Epub 2011 Dec 21. Proteins. 2012. PMID: 22189720
To test this hypothesis, we explored the impact of an allosteric effector [13(S)-hydroxyoctadeca-9(Z),11(E)-dienoic acid] on the structural properties of rabbit 12/15-LOX by small-angle X-ray scattering. ...
To test this hypothesis, we explored the impact of an allosteric effector [13(S)-hydroxyoctadeca-9(Z),11(E)-dienoic acid] on the stru …
Detecting transition radiation from a magnetic moment.
Ivanov IP, Karlovets DV. Ivanov IP, et al. Phys Rev Lett. 2013 Jun 28;110(26):264801. doi: 10.1103/PhysRevLett.110.264801. Epub 2013 Jun 26. Phys Rev Lett. 2013. PMID: 23848881
The relative contribution of the orbital angular momentum-induced magnetic moment, omega/Ee, becomes much larger than the spin-induced contribution omega/E and it can be observed experimentally. As a particular example, we consider transition radiation from vortex electron …
The relative contribution of the orbital angular momentum-induced magnetic moment, omega/Ee, becomes much larger than the spin-induced contr …