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Selective gamma-hydroxybutyric acid receptor ligands increase extracellular glutamate in the hippocampus, but fail to activate G protein and to produce the sedative/hypnotic effect of gamma-hydroxybutyric acid.
Castelli MP, Ferraro L, Mocci I, Carta F, Carai MA, Antonelli T, Tanganelli S, Cignarella G, Gessa GL. Castelli MP, et al. Among authors: mocci i. J Neurochem. 2003 Nov;87(3):722-32. doi: 10.1046/j.1471-4159.2003.02037.x. J Neurochem. 2003. PMID: 14535954 Free article.