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Kidney cancer biomarkers and targets for therapeutics: survivin (BIRC5), XIAP, MCL-1, HIF1α, HIF2α, NRF2, MDM2, MDM4, p53, KRAS and AKT in renal cell carcinoma.
J Exp Clin Cancer Res. 2021 Aug 12;40(1):254. doi: 10.1186/s13046-021-02026-1.
J Exp Clin Cancer Res. 2021.
PMID: 34384473
Free PMC article.
Review.
FL118, acting as a 'molecular glue degrader', binds to dephosphorylates and degrades the oncoprotein DDX5 (p68) to control c-Myc, survivin and mutant Kras against colorectal and pancreatic cancer with high efficacy.
Ling X, Wu W, Aljahdali IAM, Liao J, Santha S, Fountzilas C, Boland PM, Li F.
Ling X, et al. Among authors: aljahdali iam.
Clin Transl Med. 2022 May;12(5):e881. doi: 10.1002/ctm2.881.
Clin Transl Med. 2022.
PMID: 35604033
Free PMC article.
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Molecular Glues: Capable Protein-Binding Small Molecules That Can Change Protein-Protein Interactions and Interactomes for the Potential Treatment of Human Cancer and Neurodegenerative Diseases.
Li F, Aljahdali IAM, Ling X.
Li F, et al. Among authors: aljahdali iam.
Int J Mol Sci. 2022 Jun 1;23(11):6206. doi: 10.3390/ijms23116206.
Int J Mol Sci. 2022.
PMID: 35682885
Free PMC article.
Review.
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Mutant Kras as a Biomarker Plays a Favorable Role in FL118-Induced Apoptosis, Reactive Oxygen Species (ROS) Production and Modulation of Survivin, Mcl-1 and XIAP in Human Bladder Cancer.
Santha S, Ling X, Aljahdali IAM, Rasam SS, Wang X, Liao J, Wang J, Fountzilas C, Li Q, Qu J, Li F.
Santha S, et al. Among authors: aljahdali iam.
Cancers (Basel). 2020 Nov 18;12(11):3413. doi: 10.3390/cancers12113413.
Cancers (Basel). 2020.
PMID: 33217967
Free PMC article.
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