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The following term was not found in PubMed: Agustinisari
Page 1
Bioenergetics of the aging heart and skeletal muscles: Modern concepts and controversies.
Tepp K, Timohhina N, Puurand M, Klepinin A, Chekulayev V, Shevchuk I, Kaambre T. Tepp K, et al. Ageing Res Rev. 2016 Jul;28:1-14. doi: 10.1016/j.arr.2016.04.001. Epub 2016 Apr 6. Ageing Res Rev. 2016. PMID: 27063513 Review.
The functional interactions between the components of Intracellular Energetic Unit (ICEU) regulate the energy production and consumption in oxidative muscle cells. The alterations of these interactions in ICEU should be studied in order to find a more effective prot …
The functional interactions between the components of Intracellular Energetic Unit (ICEU) regulate the energy production and consumpt …
Modular organization of cardiac energy metabolism: energy conversion, transfer and feedback regulation.
Guzun R, Kaambre T, Bagur R, Grichine A, Usson Y, Varikmaa M, Anmann T, Tepp K, Timohhina N, Shevchuk I, Chekulayev V, Boucher F, Dos Santos P, Schlattner U, Wallimann T, Kuznetsov AV, Dzeja P, Aliev M, Saks V. Guzun R, et al. Acta Physiol (Oxf). 2015 Jan;213(1):84-106. doi: 10.1111/apha.12287. Epub 2014 Apr 18. Acta Physiol (Oxf). 2015. PMID: 24666671 Free PMC article. Review.
Particular attention was paid to the structure-function relationship in the development of ICEU, and the role of mitochondria interaction with cytoskeletal proteins, like tubulin, in the regulation of MOM permeability in response to energy metabolic signals providing regul …
Particular attention was paid to the structure-function relationship in the development of ICEU, and the role of mitochondria interac …
Alkylation of beta-tubulin on Glu 198 by a microtubule disrupter.
Bouchon B, Chambon C, Mounetou E, Papon J, Miot-Noirault E, Gaudreault RC, Madelmont JC, Degoul F. Bouchon B, et al. Mol Pharmacol. 2005 Nov;68(5):1415-22. doi: 10.1124/mol.105.015586. Epub 2005 Aug 12. Mol Pharmacol. 2005. PMID: 16099845
We have shown that beta-tubulin was alkylated by a microtubule disrupter, N-4-iodophenyl-N'-(2-chloroethyl)urea (ICEU), on a glutamic acid residue at position 198 and not on the previously proposed reactive cysteine 239. ICEU belongs to the 4-substituted-phenyl-N'-( …
We have shown that beta-tubulin was alkylated by a microtubule disrupter, N-4-iodophenyl-N'-(2-chloroethyl)urea (ICEU), on a glutamic …
N-4-iodophenyl-N'-2-chloroethylurea, a novel potential anticancer agent with colon-specific accumulation: radioiodination and comparative in vivo biodistribution profiles.
Mounetou E, Miot-Noirault E, Gaudreault RC, Madelmont JC. Mounetou E, et al. Invest New Drugs. 2010 Apr;28(2):124-31. doi: 10.1007/s10637-009-9222-z. Epub 2009 Feb 10. Invest New Drugs. 2010. PMID: 19205625
In this study, 4-ICEU was radiolabelled with [(125)I]iodide in order to carry out a comparative study of its in vivo behavior profile. 4-[(125)I]-ICEU was synthesized by direct electrophilic radioiodination with 80% radiochemical yield and 97% radiopurity. ...Additi …
In this study, 4-ICEU was radiolabelled with [(125)I]iodide in order to carry out a comparative study of its in vivo behavior profile …
Application of the principles of systems biology and Wiener's cybernetics for analysis of regulation of energy fluxes in muscle cells in vivo.
Guzun R, Saks V. Guzun R, et al. Int J Mol Sci. 2010 Mar 8;11(3):982-1019. doi: 10.3390/ijms11030982. Int J Mol Sci. 2010. PMID: 20479996 Free PMC article. Review.
The system of compartmentalized creatine kinase (CK) isoenzymes functionally coupled to ANT and ATPases, and mitochondrial-cytoskeletal interactions separate energy fluxes (mass and energy transfer) from signalling (information transfer) within dissipative metabolic structures - …
The system of compartmentalized creatine kinase (CK) isoenzymes functionally coupled to ANT and ATPases, and mitochondrial-cytoskeletal inte …
Antiangiogenic and antitumoral activity of phenyl-3-(2-chloroethyl)ureas: a class of soft alkylating agents disrupting microtubules that are unaffected by cell adhesion-mediated drug resistance.
Petitclerc E, Deschesnes RG, Côté MF, Marquis C, Janvier R, Lacroix J, Miot-Noirault E, Legault J, Mounetou E, Madelmont JC, C -Gaudreault R. Petitclerc E, et al. Cancer Res. 2004 Jul 1;64(13):4654-63. doi: 10.1158/0008-5472.CAN-03-3715. Cancer Res. 2004. PMID: 15231678
Here, we present results supporting our assumption that 4-tert-butyl-[3-(2-chloroethyl)ureido]phenyl (tBCEU) (and its bioisosteric derivative 4-iodo-[3-(2-chloroethyl)ureido]phenyl (ICEU) are potent antimicrotubule agents both in vitro and in vivo. ...It is noteworthy that …
Here, we present results supporting our assumption that 4-tert-butyl-[3-(2-chloroethyl)ureido]phenyl (tBCEU) (and its bioisosteric derivativ …
Diversity and Evolution of the Tn5801-tet(M)-Like Integrative and Conjugative Elements among Enterococcus, Streptococcus, and Staphylococcus.
León-Sampedro R, Novais C, Peixe L, Baquero F, Coque TM. León-Sampedro R, et al. Antimicrob Agents Chemother. 2016 Jan 4;60(3):1736-46. doi: 10.1128/AAC.01864-15. Antimicrob Agents Chemother. 2016. PMID: 26729505 Free PMC article.
We also examined 610 isolates of Enterococcus (from 10 countries, 1987 to 2010) for the presence of this and other known CTn-tet(M) elements due to the scarcity of data about Tn5801 among enterococci. Genome location (by ICeu-I-pulsed-field gel electrophoresis [PFGE] hybri …
We also examined 610 isolates of Enterococcus (from 10 countries, 1987 to 2010) for the presence of this and other known CTn-tet(M) elements …
Characterization of the covalent binding of N-phenyl-N'-(2-chloroethyl)ureas to {beta}-tubulin: importance of Glu198 in microtubule stability.
Fortin S, Bouchon B, Chambon C, Lacroix J, Moreau E, Chezal JM, Degoul F, C-Gaudreault R. Fortin S, et al. J Pharmacol Exp Ther. 2011 Feb;336(2):460-7. doi: 10.1124/jpet.110.171082. Epub 2010 Oct 26. J Pharmacol Exp Ther. 2011. PMID: 20978170
Glutamyl 198 residue in beta-tubulin (Glu198), which is adjacent to the C-BS behind the two potent nucleophilic residues, Cys239 and Cys354, has been shown to covalently react with 1-(2-chloroethyl)-3-(4-iodophenyl)urea (ICEU). By use of mass spectrometry, we have now iden …
Glutamyl 198 residue in beta-tubulin (Glu198), which is adjacent to the C-BS behind the two potent nucleophilic residues, Cys239 and Cys354, …
N-(4-iodophenyl)-N'-(2-chloroethyl)urea as a microtubule disrupter: in vitro and in vivo profiling of antitumoral activity on CT-26 murine colon carcinoma cell line cultured and grafted to mice.
Borel M, Degoul F, Communal Y, Mounetou E, Bouchon B, C-Gaudreault R, Madelmont JC, Miot-Noirault E. Borel M, et al. Br J Cancer. 2007 Jun 4;96(11):1684-91. doi: 10.1038/sj.bjc.6603778. Epub 2007 May 8. Br J Cancer. 2007. PMID: 17486131 Free PMC article.
The antitumoral profile of the microtubule disrupter N-(4-iodophenyl)-N'-(2-chloroethyl)urea (ICEU) was characterised in vitro and in vivo using the CT-26 colon carcinoma cell line, on the basis of the drug uptake by the cells, the modifications of cell cycle, and beta-tub …
The antitumoral profile of the microtubule disrupter N-(4-iodophenyl)-N'-(2-chloroethyl)urea (ICEU) was characterised in vitro and in …
Alkylation of prohibitin by cyclohexylphenyl-chloroethyl urea on an aspartyl residue is associated with cell cycle G(1) arrest in B16 cells.
Bouchon B, Papon J, Communal Y, Madelmont JC, Degoul F. Bouchon B, et al. Br J Pharmacol. 2007 Oct;152(4):449-55. doi: 10.1038/sj.bjp.0707415. Epub 2007 Aug 20. Br J Pharmacol. 2007. PMID: 17704829 Free PMC article.
Two molecules of this family, cyclohexylphenyl-chloroethyl urea (CCEU) and iodophenyl-chloroethyl urea (ICEU) induced G(1)/S and G(2)/M cell cycle blocks, respectively. ...KEY RESULTS: Several proteins (PDIA1, PDIA3, PDIA6, TRX, VDAC2) were alkylated by both ICEU an …
Two molecules of this family, cyclohexylphenyl-chloroethyl urea (CCEU) and iodophenyl-chloroethyl urea (ICEU) induced G(1)/S and G(2) …
24 results