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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1940 2
1941 2
1945 1
1946 1
1947 1
1948 4
1951 4
1952 3
1953 4
1954 8
1955 5
1956 16
1957 17
1958 19
1959 17
1960 23
1961 17
1962 20
1963 18
1964 22
1965 20
1966 17
1967 21
1968 21
1969 22
1970 35
1971 31
1972 21
1973 38
1974 33
1975 39
1976 43
1977 34
1978 32
1979 35
1980 46
1981 39
1982 51
1983 56
1984 75
1985 72
1986 79
1987 67
1988 74
1989 75
1990 77
1991 52
1992 68
1993 84
1994 87
1995 87
1996 103
1997 106
1998 102
1999 123
2000 113
2001 155
2002 177
2003 191
2004 204
2005 255
2006 296
2007 303
2008 321
2009 302
2010 327
2011 363
2012 381
2013 409
2014 411
2015 389
2016 402
2017 464
2018 485
2019 457
2020 515
2021 528
2022 521
2023 511
2024 235

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9,886 results

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Page 1
The Pregnancy-Associated Plasma Protein-A (PAPP-A) Story.
Conover CA, Oxvig C. Conover CA, et al. Endocr Rev. 2023 Nov 9;44(6):1012-1028. doi: 10.1210/endrev/bnad017. Endocr Rev. 2023. PMID: 37267421 Review.
Pregnancy-associated plasma protein-A (PAPP-A) was first identified in the early 1970s as a placental protein of unknown function, present at high concentrations in the circulation of pregnant women. ...This proteolytic regulation of IGF activity is important, since the IG …
Pregnancy-associated plasma protein-A (PAPP-A) was first identified in the early 1970s as a placental protein of unknown function, pr …
Anthropometric and biochemical correlates of PAPP-A2, free IGF-I, and IGFBP-3 in childhood.
Fujimoto M, Khoury JC, Khoury PR, Kalra B, Kumar A, Sluss P, Oxvig C, Hwa V, Dauber A. Fujimoto M, et al. Eur J Endocrinol. 2020 Mar;182(3):363-374. doi: 10.1530/EJE-19-0859. Eur J Endocrinol. 2020. PMID: 31961798 Free PMC article.
OBJECTIVE: Pregnancy-associated plasma protein-A2 (PAPP-A2) is a metalloproteinase that cleaves IGFBP-3 and IGFBP-5. ...We examined PAPP-A2 and intact IGFBP-3 levels in childhood and explored associations between PAPP-A2, free and total IGF-I, and total and i …
OBJECTIVE: Pregnancy-associated plasma protein-A2 (PAPP-A2) is a metalloproteinase that cleaves IGFBP-3 and IGFBP-5. ...We examined …
PAPP-A and the IGF system.
Monget P, Oxvig C. Monget P, et al. Ann Endocrinol (Paris). 2016 Jun;77(2):90-6. doi: 10.1016/j.ando.2016.04.015. Epub 2016 May 5. Ann Endocrinol (Paris). 2016. PMID: 27155776 Review.
Finally, PAPP-A may serve as a therapeutic target to indirectly inhibit IGF signalling in tissues where this is driven by increased PAPP-A activity. By taking advantage of the intricate interaction between PAPP-A and IGFBP-4, highly specific and selective inh …
Finally, PAPP-A may serve as a therapeutic target to indirectly inhibit IGF signalling in tissues where this is driven by increased …
Brain-specific PAPP-A knock-out mice?
Bale LK, West SA, Conover CA. Bale LK, et al. Exp Gerontol. 2021 Oct 15;154:111548. doi: 10.1016/j.exger.2021.111548. Epub 2021 Sep 9. Exp Gerontol. 2021. PMID: 34509589 Free PMC article.
PAPP-A knock-out (KO) mice are a valuable model for investigating the effects of down-regulating localized insulin-like growth factor (IGF) action, which has been shown to extend lifespan and healthspan when the PAPP-A gene is globally deleted. ...We then determined …
PAPP-A knock-out (KO) mice are a valuable model for investigating the effects of down-regulating localized insulin-like growth factor …
PAPP-A2 a new key regulator of growth.
Banaszak-Ziemska M, Niedziela M. Banaszak-Ziemska M, et al. Endokrynol Pol. 2017;68(6):682-691. doi: 10.5603/EP.a2017.0060. Endokrynol Pol. 2017. PMID: 29238946 Free article. Review.
Two proteases important for the proper functioning of the GH/IGF axis: pregnancy-associated plasma protein-A (PAPP-A) and pregnancy-associated plasma protein-A2 (PAPP-A2), have been described. The first description of the new syndrome of growth failure associated wi …
Two proteases important for the proper functioning of the GH/IGF axis: pregnancy-associated plasma protein-A (PAPP-A) and pregnancy-a …
PAPP-A: a new anti-aging target?
Conover CA. Conover CA. Aging Cell. 2010 Dec;9(6):942-6. doi: 10.1111/j.1474-9726.2010.00630.x. Epub 2010 Oct 21. Aging Cell. 2010. PMID: 20854420 Free PMC article. Review.
This article focuses on the role of PAPP-A in mammalian aging. It introduces PAPP-A and a little of its history, briefly discusses the function of PAPP-A in the insulin-like growth factor (IGF) system and the regulators of PAPP-A expression, and then r …
This article focuses on the role of PAPP-A in mammalian aging. It introduces PAPP-A and a little of its history, briefly discu …
PAPP-A in cardiac and non-cardiac conditions.
Li Y, Zhou C, Zhou X, Song L, Hui R. Li Y, et al. Clin Chim Acta. 2013 Feb 18;417:67-72. doi: 10.1016/j.cca.2012.12.006. Epub 2012 Dec 20. Clin Chim Acta. 2013. PMID: 23262366 Review.
In non-cardiac conditions, PAPP-A is a new anti-aging target. PAPP-A knock out (KO) mice have a prolonged lifespan than the wild type. In addition, PAPP-A is also a biomarker associated with malignant cancer and end stage renal disease....
In non-cardiac conditions, PAPP-A is a new anti-aging target. PAPP-A knock out (KO) mice have a prolonged lifespan than the wi …
Pregnancy-associated plasma proteins and Stanniocalcin-2 - Novel players controlling IGF-I physiology.
Frystyk J, Teran E, Gude MF, Bjerre M, Hjortebjerg R. Frystyk J, et al. Growth Horm IGF Res. 2020 Aug-Oct;53-54:101330. doi: 10.1016/j.ghir.2020.101330. Epub 2020 Jul 4. Growth Horm IGF Res. 2020. PMID: 32693362 Review.
In contrast, human findings indicate that altered PAPP-A2 activity changes circulating IGF-I concentrations, although PAPP-A2 is also present in high concentrations in tissues. ...The enzymatic activity of PAPP-A and PAPP-A2 was recently discovered to …
In contrast, human findings indicate that altered PAPP-A2 activity changes circulating IGF-I concentrations, although PAPP-A2 …
PAPP-A: a promising therapeutic target for healthy longevity.
Conover CA, Oxvig C. Conover CA, et al. Aging Cell. 2017 Apr;16(2):205-209. doi: 10.1111/acel.12564. Epub 2016 Dec 29. Aging Cell. 2017. PMID: 28035757 Free PMC article. Review.
Reduced IGF signaling has been associated with increased lifespan and healthspan. Therefore, inhibition of PAPP-A represents a novel approach to indirectly decrease the availability of bioactive IGF. Here, we will review data in support of PAPP-A as a therapeutic ta …
Reduced IGF signaling has been associated with increased lifespan and healthspan. Therefore, inhibition of PAPP-A represents a novel …
IGFBP-4 and PAPP-A in normal physiology and disease.
Hjortebjerg R. Hjortebjerg R. Growth Horm IGF Res. 2018 Aug;41:7-22. doi: 10.1016/j.ghir.2018.05.002. Epub 2018 May 30. Growth Horm IGF Res. 2018. PMID: 29864720 Review.
IGFBP-4 is the principal substrate for the enzyme pregnancy-associated plasma protein-A (PAPP-A). Through IGF-dependent cleavage of IGFBP-4 in the vicinity of the IGF receptor, PAPP-A is able to increase IGF bioavailability and stimulate IGF-mediated growth. ...Fina …
IGFBP-4 is the principal substrate for the enzyme pregnancy-associated plasma protein-A (PAPP-A). Through IGF-dependent cleavage of I …
9,886 results