New cembranolides from the Dongsha Atoll soft coral Lobophytum durum

Shi-Yie Cheng; Pei-Wen Chen; Hwa-Pyng Chen; Shang-Kwei Wang; Chang-Yih Duh

doi:10.3390/md9081307

New cembranolides from the Dongsha Atoll soft coral Lobophytum durum

Mar Drugs. 2011;9(8):1307-1318. doi: 10.3390/md9081307. Epub 2011 Jul 27.

Authors

Shi-Yie Cheng¹, Pei-Wen Chen¹, Hwa-Pyng Chen¹, Shang-Kwei Wang², Chang-Yih Duh^{1

3}

Affiliations

¹ Department of Marine Biotechnology and Resources, National Sun Yat-sen University, Kaohsiung 804, Taiwan.
² Department of Microbiology, Kaohsiung Medical University, Kaohsiung 807, Taiwan.
³ Center for Asia-Pacific Ocean Research and Translational Biopharmaceuticals, National Sun Yat-sen University, Kaohsiung 804, Taiwan.

Abstract

Chemical investigations of the Dongsha Atoll soft coral Lobophytum durum resulted in the isolation of five new cembranolides, durumolides M-Q (1-5). The structures of compounds 1-5 were characterized by the interpretation of extensive spectroscopic analysis. Compound 4 exhibited cytotoxicity against P-388 (mouse lymphocytic leukemia) cell line with an ED₅₀ of 3.8 μg/mL. Moreover, compound 5 showed significant antiviral activity against human cytomegalovirus with an IC₅₀ of 5.2 μg/mL.

Keywords: Lobophytum durum; antiviral activity; cytotoxicity; soft coral.

Publication types

Research Support, Non-U.S. Gov't

MeSH terms

Animals
Anthozoa / chemistry*
Cell Line, Tumor
Cytomegalovirus / drug effects
Diterpenes / chemistry*
Diterpenes / isolation & purification
Diterpenes / pharmacology*
Drug Screening Assays, Antitumor
HT29 Cells
Humans
Inhibitory Concentration 50
Magnetic Resonance Spectroscopy / methods
Mice

Substances

Diterpenes