Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My NCBI Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1947 3
1948 3
1950 2
1951 1
1952 1
1954 1
1955 2
1956 1
1957 3
1958 3
1959 4
1960 3
1961 11
1962 10
1963 10
1964 9
1965 4
1966 5
1967 4
1968 2
1969 8
1970 1
1971 3
1972 2
1973 1
1974 3
1975 9
1976 1
1977 5
1978 3
1979 12
1980 8
1981 7
1982 9
1983 11
1984 9
1985 13
1986 15
1987 22
1988 21
1989 13
1990 16
1991 20
1992 19
1993 12
1994 23
1995 21
1996 15
1997 13
1998 16
1999 23
2000 29
2001 20
2002 26
2003 20
2004 22
2005 31
2006 28
2007 37
2008 33
2009 52
2010 58
2011 48
2012 50
2013 55
2014 50
2015 62
2016 74
2017 66
2018 75
2019 82
2020 83
2021 88
2022 78
2023 85
2024 23

Text availability

Article attribute

Article type

Publication date

Search Results

1,542 results

Results by year

Filters applied: . Clear all
Page 1
Showing results for human malic
Search for Humna Malik instead (2 results)
Dual Effects of Alpha-Hydroxy Acids on the Skin.
Tang SC, Yang JH. Tang SC, et al. Molecules. 2018 Apr 10;23(4):863. doi: 10.3390/molecules23040863. Molecules. 2018. PMID: 29642579 Free PMC article. Review.
AHAs are organic acids with one hydroxyl group attached to the alpha position of the acid. AHAs including glycolic acid, lactic acid, malic acid, tartaric acid, and citric acid are often used extensively in cosmetic formulations. ...The aim of this manuscript is to review …
AHAs are organic acids with one hydroxyl group attached to the alpha position of the acid. AHAs including glycolic acid, lactic acid, mal …
Targeting human mitochondrial NAD(P)(+)-dependent malic enzyme (ME2) impairs energy metabolism and redox state and exhibits antileukemic activity in acute myeloid leukemia.
Chen KC, Hsiao IH, Huang YN, Chou YT, Lin YC, Hsieh JY, Chang YL, Wu KH, Liu GY, Hung HC. Chen KC, et al. Cell Oncol (Dordr). 2023 Oct;46(5):1301-1316. doi: 10.1007/s13402-023-00812-x. Epub 2023 Apr 20. Cell Oncol (Dordr). 2023. PMID: 37079187 Free PMC article.
Acute myeloid leukemia (AML) is a fast-growing and highly fatal blood cancer, and recent research has shown that targeting metabolism may be a promising therapeutic approach for treating AML. One promising target is the human mitochondrial NAD(P)(+)-dependent malic …
Acute myeloid leukemia (AML) is a fast-growing and highly fatal blood cancer, and recent research has shown that targeting metabolism may be …
Malic enzyme 2 maintains protein stability of mutant p53 through 2-hydroxyglutarate.
Zhao M, Yao P, Mao Y, Wu J, Wang W, Geng C, Cheng J, Du W, Jiang P. Zhao M, et al. Nat Metab. 2022 Feb;4(2):225-238. doi: 10.1038/s42255-022-00532-w. Epub 2022 Feb 28. Nat Metab. 2022. PMID: 35228743
Here we show that cancer-associated mutant p53 protein is stabilized by 2-hydroxyglutarate generated by malic enzyme 2. Mechanistically, malic enzyme 2 promotes the production of 2-hydroxyglutarate by adjusting glutaminolysis, as well as through a reaction that requ …
Here we show that cancer-associated mutant p53 protein is stabilized by 2-hydroxyglutarate generated by malic enzyme 2. Mechanistical …
Treatment of xerostomia and hyposalivation in the elderly: A systematic review.
Gil-Montoya JA, Silvestre FJ, Barrios R, Silvestre-Rangil J. Gil-Montoya JA, et al. Med Oral Patol Oral Cir Bucal. 2016 May 1;21(3):e355-66. doi: 10.4317/medoral.20969. Med Oral Patol Oral Cir Bucal. 2016. PMID: 27031061 Free PMC article. Review.
The "Clinical Trial", from 2006 to March 2015, was carried out in English and only on human cases. The draft of the systematic review and assessment of the methodological quality of the trials was carried out following the criteria of PRISMA (Preferred Reporting Items for …
The "Clinical Trial", from 2006 to March 2015, was carried out in English and only on human cases. The draft of the systematic review …
Suppression of the human malic enzyme 2 modifies energy metabolism and inhibits cellular respiration.
Hsieh JY, Chen KC, Wang CH, Liu GY, Ye JA, Chou YT, Lin YC, Lyu CJ, Chang RY, Liu YL, Li YH, Lee MR, Ho MC, Hung HC. Hsieh JY, et al. Commun Biol. 2023 May 22;6(1):548. doi: 10.1038/s42003-023-04930-y. Commun Biol. 2023. PMID: 37217557 Free PMC article.
Human mitochondrial NAD(P)(+)-dependent malic enzyme (ME2) is well-known for its role in cell metabolism, which may be involved in cancer or epilepsy. ...
Human mitochondrial NAD(P)(+)-dependent malic enzyme (ME2) is well-known for its role in cell metabolism, which may be involve …
NRF2 Activation Reprograms Defects in Oxidative Metabolism to Restore Macrophage Function in Chronic Obstructive Pulmonary Disease.
Ryan EM, Sadiku P, Coelho P, Watts ER, Zhang A, Howden AJM, Sanchez-Garcia MA, Bewley M, Cole J, McHugh BJ, Vermaelen W, Ghesquiere B, Carmeliet P, Rodriguez Blanco G, Von Kriegsheim A, Sanchez Y, Rumsey W, Callahan JF, Cooper G, Parkinson N, Baillie K, Cantrell DA, McCafferty J, Choudhury G, Singh D, Dockrell DH, Whyte MKB, Walmsley SR. Ryan EM, et al. Am J Respir Crit Care Med. 2023 Apr 15;207(8):998-1011. doi: 10.1164/rccm.202203-0482OC. Am J Respir Crit Care Med. 2023. PMID: 36724365 Free PMC article.
Defects in oxidative metabolism extend to an impaired redox balance associated with defective expression of the NADPH-generating enzyme, ME1 (malic enzyme 1), a known target of the antioxidant transcription factor NRF2 (nuclear factor erythroid 2-related factor 2). ...
Defects in oxidative metabolism extend to an impaired redox balance associated with defective expression of the NADPH-generating enzyme, ME1 …
Integrative structural and functional analysis of human malic enzyme 3: A potential therapeutic target for pancreatic cancer.
Grell TAJ, Mason M, Thompson AA, Gómez-Tamayo JC, Riley D, Wagner MV, Steele R, Ortiz-Meoz RF, Wadia J, Shaffer PL, Tresadern G, Sharma S, Yu X. Grell TAJ, et al. Heliyon. 2022 Dec 19;8(12):e12392. doi: 10.1016/j.heliyon.2022.e12392. eCollection 2022 Dec. Heliyon. 2022. PMID: 36590518 Free PMC article.
Malic enzymes (ME1, ME2, and ME3) are involved in cellular energy regulation, redox homeostasis, and biosynthetic processes, through the production of pyruvate and reducing agent NAD(P)H. Recent studies have implicated the third and least well-characterized isoform, mitoch …
Malic enzymes (ME1, ME2, and ME3) are involved in cellular energy regulation, redox homeostasis, and biosynthetic processes, through …
Fumarase activity in NAD-dependent malic enzyme, MaeA, from Escherichia coli.
Afzal AR, Jeon J, Jung CH. Afzal AR, et al. Biochem Biophys Res Commun. 2023 Oct 20;678:144-147. doi: 10.1016/j.bbrc.2023.08.045. Epub 2023 Aug 22. Biochem Biophys Res Commun. 2023. PMID: 37634412
NAD-dependent malic enzymes catalyze NAD reduction to NADH while converting malate to pyruvate and CO(2). ...Human ME2, an NAD-dependent malic enzyme, also converted NAD to NADH in the presence of fumarate, suggesting that the duplex activity as fumarase and …
NAD-dependent malic enzymes catalyze NAD reduction to NADH while converting malate to pyruvate and CO(2). ...Human ME2, an NAD …
Malic enzyme 2 as a potential therapeutic drug target for cancer.
Sarfraz I, Rasul A, Hussain G, Hussain SM, Ahmad M, Nageen B, Jabeen F, Selamoglu Z, Ali M. Sarfraz I, et al. IUBMB Life. 2018 Nov;70(11):1076-1083. doi: 10.1002/iub.1930. Epub 2018 Aug 29. IUBMB Life. 2018. PMID: 30160039 Free article. Review.
The aberrant expression pattern of enzymatic machineries orchestrates metabolic activities into a platform that ultimately promotes cellular growth, survival, and proliferation. The NADP(+)-dependent mitochondrial malic enzyme 2 (ME2) has been widely appreciated due to its …
The aberrant expression pattern of enzymatic machineries orchestrates metabolic activities into a platform that ultimately promotes cellular …
Malic enzyme 1 (ME1) in the biology of cancer: it is not just intermediary metabolism.
Simmen FA, Alhallak I, Simmen RCM. Simmen FA, et al. J Mol Endocrinol. 2020 Nov;65(4):R77-R90. doi: 10.1530/JME-20-0176. J Mol Endocrinol. 2020. PMID: 33064660 Free PMC article. Review.
Malic enzyme 1 (ME1) is a cytosolic protein that catalyzes the conversion of malate to pyruvate while concomitantly generating NADPH from NADP. ...
Malic enzyme 1 (ME1) is a cytosolic protein that catalyzes the conversion of malate to pyruvate while concomitantly generating NADPH …
1,542 results