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Showing results for huisgen yang
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Cascade Ring-Opening/Cyclization Reaction of Spiro(nitrocyclopropane)oxindoles with Huisgen Zwitterions and Synthesis of Pyrazolo[3,4-b]indoles.
Tang T, Wang Q, Cao S, Yang CJ, He Z. Tang T, et al. J Org Chem. 2022 Dec 16;87(24):16707-16721. doi: 10.1021/acs.joc.2c02375. Epub 2022 Dec 6. J Org Chem. 2022. PMID: 36473167
Herein, we report a ring-opening/cyclization cascade reaction of spiro(nitrocyclopropane)oxindoles with in situ generated Huisgen zwitterions (HZs) from PPh(3) and azodicarboxylates. This reaction provides an array of polyfunctionalized pyrazolo[3,4-b]indole derivatives in …
Herein, we report a ring-opening/cyclization cascade reaction of spiro(nitrocyclopropane)oxindoles with in situ generated Huisgen zwi …
Ether Naphthotube Host-Guest Complexes and [2]Rotaxanes with Dications.
Zheng LS, Wang SM, Jiang W, Wang LL, Yang LP. Zheng LS, et al. Chemistry. 2024 Apr 2:e202401079. doi: 10.1002/chem.202401079. Online ahead of print. Chemistry. 2024. PMID: 38563628
Based on the host-guest complexes composed of ether naphthotube and organic cations, two interlocked [2]rotaxanes were prepared by cationization reaction and Huisgen cycloaddition between the cations and the stopper components. ...
Based on the host-guest complexes composed of ether naphthotube and organic cations, two interlocked [2]rotaxanes were prepared by cationiza …
Copper-catalyzed Huisgen and oxidative Huisgen coupling reactions controlled by polysiloxane-supported amines (AFPs) for the divergent synthesis of triazoles and bistriazoles.
Zheng ZJ, Ye F, Zheng LS, Yang KF, Lai GQ, Xu LW. Zheng ZJ, et al. Chemistry. 2012 Oct 29;18(44):14094-9. doi: 10.1002/chem.201202472. Epub 2012 Sep 27. Chemistry. 2012. PMID: 23018981
In this manuscript, we demonstrate the remarkable ability of the secondary amine-functional polysiloxane to induce oxidative coupling in the copper-mediated Huisgen reactions of azides and alkynes, thereby achieving good yields and selectivities. ...Comparably, it is also …
In this manuscript, we demonstrate the remarkable ability of the secondary amine-functional polysiloxane to induce oxidative coupling in the …
Jump-seq: Genome-Wide Capture and Amplification of 5-Hydroxymethylcytosine Sites.
Hu L, Liu Y, Han S, Yang L, Cui X, Gao Y, Dai Q, Lu X, Kou X, Zhao Y, Sheng W, Gao S, He X, He C. Hu L, et al. J Am Chem Soc. 2019 Jun 5;141(22):8694-8697. doi: 10.1021/jacs.9b02512. Epub 2019 May 23. J Am Chem Soc. 2019. PMID: 31117646 Free PMC article.
The principle of this method is to label 5hmC by the 6- N3-glucose moiety and connect a hairpin DNA oligonucleotide carrying an alkyne group to the azide-modified 5hmC via Huisgen cycloaddition (click) chemistry. Primer extension starts from the hairpin motif to the modifi …
The principle of this method is to label 5hmC by the 6- N3-glucose moiety and connect a hairpin DNA oligonucleotide carrying an alkyne group …
Sequential annulation and isomerisation reaction of 3-acylmethylidene oxindoles with Huisgen zwitterions and synthesis of 5-(3-oxindolyl)oxazoles.
Xue F, Yang CJ, Tang T, He Z. Xue F, et al. Org Biomol Chem. 2023 Oct 18;21(40):8176-8181. doi: 10.1039/d3ob01199b. Org Biomol Chem. 2023. PMID: 37786314
Herein, we report a facile synthesis of 5-(3-oxindolyl)oxazole derivatives via a sequential annulation and isomerisation reaction of 3-acylmethylidene oxindoles with in situ generated Huisgen zwitterions (HZs) from PPh(3) and azodicarboxylates. This reaction exhibits good …
Herein, we report a facile synthesis of 5-(3-oxindolyl)oxazole derivatives via a sequential annulation and isomerisation reaction of 3-acylm …
Isatin 1,2,3-triazoles as potent inhibitors against caspase-3.
Jiang Y, Hansen TV. Jiang Y, et al. Bioorg Med Chem Lett. 2011 Mar 15;21(6):1626-9. doi: 10.1016/j.bmcl.2011.01.110. Epub 2011 Jan 31. Bioorg Med Chem Lett. 2011. PMID: 21324681
Sixteen disubstituted 1,2,3-triazoles were prepared using the Huisgen cycloaddition reaction and evaluated as inhibitors against caspase-3. ...
Sixteen disubstituted 1,2,3-triazoles were prepared using the Huisgen cycloaddition reaction and evaluated as inhibitors against casp …
Poly(hydrophobic amino acid) Conjugates for the Delivery of Multiepitope Vaccine against Group A Streptococcus.
Azuar A, Shibu MA, Adilbish N, Marasini N, Hung H, Yang J, Luo Y, Khalil ZG, Capon RJ, Hussein WM, Toth I, Skwarczynski M. Azuar A, et al. Bioconjug Chem. 2021 Nov 17;32(11):2307-2317. doi: 10.1021/acs.bioconjchem.1c00333. Epub 2021 Aug 11. Bioconjug Chem. 2021. PMID: 34379392
The vaccine components were conjugated together (using mercapto-maleimide and azide-alkyne Huisgen cycloaddition reactions) or delivered as a mixture. The conjugated multiepitope vaccine candidate self-assembled into small nanoparticles and chain-like aggregated nanopartic …
The vaccine components were conjugated together (using mercapto-maleimide and azide-alkyne Huisgen cycloaddition reactions) or delive …
Synthesis and anti-proliferative activity of allogibberic acid derivatives containing 1,2,3-triazole pharmacophore.
Wu MJ, Wu DM, Chen JB, Zhao JF, Gong L, Gong YX, Li Y, Yang XD, Zhang H. Wu MJ, et al. Bioorg Med Chem Lett. 2018 Aug 1;28(14):2543-2549. doi: 10.1016/j.bmcl.2018.05.038. Epub 2018 May 18. Bioorg Med Chem Lett. 2018. PMID: 29884535
The key chemical processes include aromatization of the A ring in gibberellins, formation of allogibberic azides and its copper mediated Huisgen 1,3-dipolar cycloaddition with alkynes. A number of hybrids containing alpha,beta-unsaturated ketone moiety exhibited excellent …
The key chemical processes include aromatization of the A ring in gibberellins, formation of allogibberic azides and its copper mediated …
24 results