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Showing results for huisgen liu
Search for Huigen Liu instead (2 results)
Ag(2)O-Induced Regioselective Huisgen Cycloaddition for the Synthesis of Fully Substituted Pyrazoles as Potential Anticancer Agents.
Xu Q, Jia J, Wu Y, Hu B, Xin J, Liu Y, Gao W, Li D. Xu Q, et al. J Org Chem. 2022 Nov 4;87(21):14496-14506. doi: 10.1021/acs.joc.2c01910. Epub 2022 Oct 24. J Org Chem. 2022. PMID: 36278313
Efficient regioselective synthesis of novel fully substituted pyrazoles has been achieved through Huisgen cycloaddition reaction of delta-acetoxy allenoates with hydrazonoyl chlorides by the addition of Ag(2)O. ...
Efficient regioselective synthesis of novel fully substituted pyrazoles has been achieved through Huisgen cycloaddition reaction of d …
Huisgen's 1,3-Dipolar Cycloadditions to Fulvenes Proceed via Ambimodal [6+4]/[4+2] Transition States.
Liu F, Chen Y, Houk KN. Liu F, et al. Angew Chem Int Ed Engl. 2020 Jul 20;59(30):12412-12416. doi: 10.1002/anie.202005265. Epub 2020 Jun 29. Angew Chem Int Ed Engl. 2020. PMID: 32384185
Huisgen's 1960 announcement of the concept of 1,3-dipolar cycloadditions was published the year before Alder's study of the reaction of diazomethane and dimethylfulvene. ...We dedicate this paper to the extraordinary life and humanity of Rolf Huisgen, and to …
Huisgen's 1960 announcement of the concept of 1,3-dipolar cycloadditions was published the year before Alder's study of the re …
Condensation of 1,2-dicarbonyl compounds with modified Huisgen zwitterions: synthesis of N-aryl-N-acyl hydrazones.
Liu J, Cao J, Liu R, Li R, Qiao Y, Zhou R. Liu J, et al. Org Biomol Chem. 2020 Jan 22;18(3):530-537. doi: 10.1039/c9ob02508a. Org Biomol Chem. 2020. PMID: 31854422
Mechanistic investigation based on 31P NMR tracking experiments unveils that the reaction is initiated with the in situ formation of the modified Huisgen zwitterions from arylazocarboxylates and PPh3 and proceeds via a nitrogen to nitrogen ester group migration process. Th …
Mechanistic investigation based on 31P NMR tracking experiments unveils that the reaction is initiated with the in situ formation of the mod …
Click chemistry, a powerful tool for pharmaceutical sciences.
Hein CD, Liu XM, Wang D. Hein CD, et al. Pharm Res. 2008 Oct;25(10):2216-30. doi: 10.1007/s11095-008-9616-1. Epub 2008 May 29. Pharm Res. 2008. PMID: 18509602 Free PMC article. Review.
While there are a number of reactions that fulfill the criteria, the Huisgen 1,3-dipolar cycloaddition of azides and terminal alkynes has emerged as the frontrunner. It has found applications in a wide variety of research areas, including materials sciences, polymer chemis …
While there are a number of reactions that fulfill the criteria, the Huisgen 1,3-dipolar cycloaddition of azides and terminal alkynes …
Synthesis and Antitumor Activity of 1-Substituted 1,2,3-Triazole-Mollugin Derivatives.
Luo H, Lv YF, Zhang H, Hu JM, Li HM, Liu SJ. Luo H, et al. Molecules. 2021 May 28;26(11):3249. doi: 10.3390/molecules26113249. Molecules. 2021. PMID: 34071319 Free PMC article.
A new series of mollugin-1,2,3-triazole derivatives were synthesized using a copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition reaction of corresponding O-propargylated mollugin with aryl azides. ...
A new series of mollugin-1,2,3-triazole derivatives were synthesized using a copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition re …
Novel aryltriazole acyclic C-azanucleosides as anticancer candidates.
Zhang Y, Lin Y, Hou Q, Liu X, Pricl S, Peng L, Xia Y. Zhang Y, et al. Org Biomol Chem. 2020 Dec 21;18(47):9689-9699. doi: 10.1039/d0ob02164d. Epub 2020 Nov 24. Org Biomol Chem. 2020. PMID: 33232421
With the aim of searching for novel bioactive nucleosides, we developed an efficient synthetic way to construct a series of aryl 1,2,3-triazole acyclic C-azanucleosides via Huisgen 1,3-dipolar cycloaddition. The aryl 1,2,3-triazole motifs within these azanucleosides showed …
With the aim of searching for novel bioactive nucleosides, we developed an efficient synthetic way to construct a series of aryl 1,2,3-triaz …
Jump-seq: Genome-Wide Capture and Amplification of 5-Hydroxymethylcytosine Sites.
Hu L, Liu Y, Han S, Yang L, Cui X, Gao Y, Dai Q, Lu X, Kou X, Zhao Y, Sheng W, Gao S, He X, He C. Hu L, et al. J Am Chem Soc. 2019 Jun 5;141(22):8694-8697. doi: 10.1021/jacs.9b02512. Epub 2019 May 23. J Am Chem Soc. 2019. PMID: 31117646 Free PMC article.
The principle of this method is to label 5hmC by the 6- N3-glucose moiety and connect a hairpin DNA oligonucleotide carrying an alkyne group to the azide-modified 5hmC via Huisgen cycloaddition (click) chemistry. Primer extension starts from the hairpin motif to the modifi …
The principle of this method is to label 5hmC by the 6- N3-glucose moiety and connect a hairpin DNA oligonucleotide carrying an alkyne group …
Efficient synthesis of linear multifunctional poly(ethylene glycol) by copper(I)-catalyzed Huisgen 1,3-dipolar cycloaddition.
Liu XM, Thakur A, Wang D. Liu XM, et al. Biomacromolecules. 2007 Sep;8(9):2653-8. doi: 10.1021/bm070430i. Epub 2007 Aug 10. Biomacromolecules. 2007. PMID: 17688321
A short acetylene-terminated PEG was linked by 2,2-bis(azidomethyl)propane-1,3-diol using Cu(I)-catalyzed Huisgen 1,3-dipolar cycloaddition in water at room temperature. High-molecular-weight PEGs with pendant hydroxyl groups were obtained and characterized by 1H NMR and s …
A short acetylene-terminated PEG was linked by 2,2-bis(azidomethyl)propane-1,3-diol using Cu(I)-catalyzed Huisgen 1,3-dipolar cycload …
Spatiotemporally Controlled Photolabeling of Genetically Unmodified Proteins in Live Cells.
Yu H, Wang S, Fu Y, Wagner M, Weil T, Liu S, Zhao W, Zhong F, Wu Y. Yu H, et al. Anal Chem. 2024 Feb 6;96(5):1932-1940. doi: 10.1021/acs.analchem.3c04099. Epub 2024 Jan 19. Anal Chem. 2024. PMID: 38241704
., biotin, a peptide short chain) via acylation or (in cell) Huisgen cycloaddition, this affinity-driven photoclick chemistry opens up enormous opportunities for discovering dynamic functions and mechanistic interrogation of endogenous proteins in live cells....
., biotin, a peptide short chain) via acylation or (in cell) Huisgen cycloaddition, this affinity-driven photoclick chemistry opens u …
Synthesis of low surface-energy polyepichlorohydrin triazoles thin film.
Liu YY, Cheng CC, Lee DJ. Liu YY, et al. J Colloid Interface Sci. 2019 Mar 15;539:481-489. doi: 10.1016/j.jcis.2018.12.102. Epub 2018 Dec 29. J Colloid Interface Sci. 2019. PMID: 30611043
The chlorine on PECH was first replaced by an azide group, and this attached azide was then converted to a triazole group with alkyl chains using the azide-alkyne Huisgen cycloaddition reaction. Analyses confirmed the structure of final product, PECH-triazole polymer. ...
The chlorine on PECH was first replaced by an azide group, and this attached azide was then converted to a triazole group with alkyl chains …
43 results