Abstract
A new hydroxychavicol dimer, 2-(g'-hydroxychavicol)-hydroxychavicol (1), was isolated from the roots of Piper betle Linn. along with five known compounds, hydroxychavicol (2), aristololactam A II (3), aristololactam B II (4), piperolactam A (5) and cepharadione A (6). The structures of these isolated compounds were elucidated by spectroscopic methods. Compounds 1 and 2 exhibited inhibitory effects on the generation of superoxide anion and the release of elastase by human neutrophils.
Publication types
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Research Support, Non-U.S. Gov't
MeSH terms
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Anti-Inflammatory Agents / chemistry
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Anti-Inflammatory Agents / pharmacology
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Eugenol / analogs & derivatives*
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Eugenol / chemistry
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Eugenol / pharmacology
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Humans
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Neutrophils / drug effects
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Neutrophils / metabolism
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Nuclear Magnetic Resonance, Biomolecular
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Pancreatic Elastase / metabolism*
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Piper betle / chemistry*
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Plant Extracts / chemistry*
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Plant Extracts / isolation & purification
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Plant Roots / chemistry*
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Superoxides / metabolism*
Substances
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Anti-Inflammatory Agents
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Plant Extracts
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Superoxides
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2-hydroxychavicol
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Eugenol
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Pancreatic Elastase