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Year Number of Results
2005 2
2014 1
2015 2
2016 3
2017 4
2018 3
2019 3
2020 2
2021 2
2022 3
2023 4
2024 4

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29 results

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Page 1
Genomic and Transcriptomic Landscape of Triple-Negative Breast Cancers: Subtypes and Treatment Strategies.
Jiang YZ, Ma D, Suo C, Shi J, Xue M, Hu X, Xiao Y, Yu KD, Liu YR, Yu Y, Zheng Y, Li X, Zhang C, Hu P, Zhang J, Hua Q, Zhang J, Hou W, Ren L, Bao D, Li B, Yang J, Yao L, Zuo WJ, Zhao S, Gong Y, Ren YX, Zhao YX, Yang YS, Niu Z, Cao ZG, Stover DG, Verschraegen C, Kaklamani V, Daemen A, Benson JR, Takabe K, Bai F, Li DQ, Wang P, Shi L, Huang W, Shao ZM. Jiang YZ, et al. Cancer Cell. 2019 Mar 18;35(3):428-440.e5. doi: 10.1016/j.ccell.2019.02.001. Epub 2019 Mar 7. Cancer Cell. 2019. PMID: 30853353 Free article.
We classified TNBCs into four transcriptome-based subtypes: (1) luminal androgen receptor (LAR), (2) immunomodulatory, (3) basal-like immune-suppressed, and (4) mesenchymal-like. Putative therapeutic targets or biomarkers were identified among each subtype. ...
We classified TNBCs into four transcriptome-based subtypes: (1) luminal androgen receptor (LAR), (2) immunomodulatory, (3) basal-like immune …
Rab32 promotes glioblastoma migration and invasion via regulation of ERK/Drp1-mediated mitochondrial fission.
Chen P, Lu Y, He B, Xie T, Yan C, Liu T, Wu S, Yeh Y, Li Z, Huang W, Zhang X. Chen P, et al. Cell Death Dis. 2023 Mar 15;14(3):198. doi: 10.1038/s41419-023-05721-3. Cell Death Dis. 2023. PMID: 36922509 Free PMC article.
Rab32 regulates ERK(1/2)/Drp1-dependent mitochondrial fission and causes mesenchymal transition, promoting migration and invasion of GBM. It serves as a novel therapeutic target for GBM, especially for the most malignant mesenchymal subtype. ...
Rab32 regulates ERK(1/2)/Drp1-dependent mitochondrial fission and causes mesenchymal transition, promoting migration and invasion of GBM. It …
Integrated multiomic profiling of breast cancer in the Chinese population reveals patient stratification and therapeutic vulnerabilities.
Jiang YZ, Ma D, Jin X, Xiao Y, Yu Y, Shi J, Zhou YF, Fu T, Lin CJ, Dai LJ, Liu CL, Zhao S, Su GH, Hou W, Liu Y, Chen Q, Yang J, Zhang N, Zhang WJ, Liu W, Ge W, Yang WT, You C, Gu Y, Kaklamani V, Bertucci F, Verschraegen C, Daemen A, Shah NM, Wang T, Guo T, Shi L, Perou CM, Zheng Y, Huang W, Shao ZM. Jiang YZ, et al. Nat Cancer. 2024 Apr;5(4):673-690. doi: 10.1038/s43018-024-00725-0. Epub 2024 Feb 12. Nat Cancer. 2024. PMID: 38347143
Furthermore, comprehensive metabolomic and proteomic analyses revealed ferroptosis as a potential therapeutic target for basal-like tumors. The integration of clinical, transcriptomic, metabolomic, radiomic and pathological features allowed for efficient stratification of …
Furthermore, comprehensive metabolomic and proteomic analyses revealed ferroptosis as a potential therapeutic target for basal-like t …
Homogeneous Antibody-Drug Conjugates via Glycoengineering.
Tang F, Shi W, Huang W. Tang F, et al. Methods Mol Biol. 2019;2033:221-238. doi: 10.1007/978-1-4939-9654-4_15. Methods Mol Biol. 2019. PMID: 31332757
First, an azido-tagged unnatural N-glycan substrate is transferred onto Fc glycosites of a therapeutic antibody through Endo-S-catalyzed glycoremodeling, followed by click reaction with an alkyne-tagged payload drug to give a well-defined gsADC. ...
First, an azido-tagged unnatural N-glycan substrate is transferred onto Fc glycosites of a therapeutic antibody through Endo-S-cataly …
GPR65 sensing tumor-derived lactate induces HMGB1 release from TAM via the cAMP/PKA/CREB pathway to promote glioma progression.
Yan C, Yang Z, Chen P, Yeh Y, Sun C, Xie T, Huang W, Zhang X. Yan C, et al. J Exp Clin Cancer Res. 2024 Apr 4;43(1):105. doi: 10.1186/s13046-024-03025-8. J Exp Clin Cancer Res. 2024. PMID: 38576043 Free PMC article.
GPR65, selectively highly expressed on TAMs in glioma, sensed lactate stimulation and fostered HMGB1 secretion via the cAMP/PKA/CREB signaling pathway. Blocking this feedback loop presents a promising therapeutic strategy for GBM....
GPR65, selectively highly expressed on TAMs in glioma, sensed lactate stimulation and fostered HMGB1 secretion via the cAMP/PKA/CREB signali …
Biomechanical forces and force-triggered drug delivery in tumor neovascularization.
Wendong Y, Jiali J, Qiaomei F, Yayun W, Xianze X, Zheng S, Wei H. Wendong Y, et al. Biomed Pharmacother. 2024 Feb;171:116117. doi: 10.1016/j.biopha.2023.116117. Epub 2024 Jan 3. Biomed Pharmacother. 2024. PMID: 38171243 Free article. Review.
Understanding the regulatory mechanism of biomechanical forces in tumor angiogenesis is beneficial for better identifying and even taming the mechanical forces involved in angiogenesis, providing new therapeutic targets for tumor vascular normalization. Therefore, we summa …
Understanding the regulatory mechanism of biomechanical forces in tumor angiogenesis is beneficial for better identifying and even taming th …
Identification of 4-(2-furanyl)pyrimidin-2-amines as Janus kinase 2 inhibitors.
Wang Y, Huang W, Xin M, Chen P, Gui L, Zhao X, Tang F, Wang J, Liu F. Wang Y, et al. Bioorg Med Chem. 2017 Jan 1;25(1):75-83. doi: 10.1016/j.bmc.2016.10.011. Epub 2016 Oct 11. Bioorg Med Chem. 2017. PMID: 27771180
Janus kinases inhibitor is considered to have therapeutic potential for the treatment of oncology and immune-inflammatory diseases. ...
Janus kinases inhibitor is considered to have therapeutic potential for the treatment of oncology and immune-inflammatory diseases. . …
Enhanced transglycosylation activity of an Endo-F3 mutant by ligand-directed localization.
Zou X, Liu Z, Liu L, Shi W, Li W, Guo Z, Tang F, Huang W. Zou X, et al. Org Biomol Chem. 2022 Apr 13;20(15):3086-3095. doi: 10.1039/d2ob00030j. Org Biomol Chem. 2022. PMID: 35166761
At present, numerous studies have been reported to remodel the N-glycans of therapeutic antibodies for the gain of functions. Among the ways of remodeling antibody N-glycans, the chemoenzymatic glycoengineering approach by endoglycosidase (ENGase) has been deeply investiga …
At present, numerous studies have been reported to remodel the N-glycans of therapeutic antibodies for the gain of functions. Among t …
Synthesis of Branched Peptides via a Side-Chain Benzyl Ester.
Liu J, Li J, Tian X, Tang F, Huang W. Liu J, et al. Methods Mol Biol. 2020;2103:189-198. doi: 10.1007/978-1-0716-0227-0_12. Methods Mol Biol. 2020. PMID: 31879926
Branched peptide as an attractive mimic of natural peptide is widely used in structural design of functional or therapeutic peptides, to improve their biological activity, stability, and pharmacokinetic properties. ...
Branched peptide as an attractive mimic of natural peptide is widely used in structural design of functional or therapeutic peptides, …
Design, synthesis, and biological evaluation of novel discoidin domain receptor inhibitors for the treatment of lung adenocarcinoma and pulmonary fibrosis.
Liu S, Li X, Chen C, Lin X, Zuo W, Peng C, Jiang Q, Huang W, He G. Liu S, et al. Eur J Med Chem. 2024 Feb 5;265:116100. doi: 10.1016/j.ejmech.2023.116100. Epub 2023 Dec 30. Eur J Med Chem. 2024. PMID: 38171149
Overall, these findings highlight the potential of these novel DDR1 inhibitors as promising therapeutic candidates for the treatment of DDR-related diseases....
Overall, these findings highlight the potential of these novel DDR1 inhibitors as promising therapeutic candidates for the treatment …
29 results