Agricultural water salvation is the lifeblood of the national economy and is of great significance to the high-quality development of the region. In order to maximize the economic assistances of agricultural water salvation investment, this article focuses on panel data from 2005 to 2019 in 14 provinces in Eastern China, this research constructs an economic development evaluation index system from five dimensions: innovative development, coordinated development, green development, open development and shared development, and uses dynamic panel model to explore the influence relationship and path of Eastern Agricultural water salvation investment on economic development. The results represent that: there is a significant non-linear effect between agricultural water salvation investment and economic growth, showing an inverted U-shaped relationship. Which means that with the expansion of agricultural water salvation investment; economic growth has risen first and then declined. At present, the impact of agricultural water salvation investment in the Eastern region on economic development is in the promotion stage of positive and sustained growth. The recommendation of this research will help the state control in the amount of agricultural water salvation investment in the Eastern region, improve the efficiency of agricultural water salvation investment, and provide support in decision making.