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Potent and specific Atg8-targeting autophagy inhibitory peptides from giant ankyrins.
Li J, Zhu R, Chen K, Zheng H, Zhao H, Yuan C, Zhang H, Wang C, Zhang M. Li J, et al. Nat Chem Biol. 2018 Aug;14(8):778-787. doi: 10.1038/s41589-018-0082-8. Epub 2018 Jun 4. Nat Chem Biol. 2018. PMID: 29867141
Here we discover a super-strong GABARAP-selective inhibitory peptide harbored in 270/480 kDa ankyrin-G and a super-potent pan-Atg8 inhibitory peptide from 440 kDa ankyrin-B. Structural studies elucidate the mechanism governing the Atg8 binding potency and selectivity of th …
Here we discover a super-strong GABARAP-selective inhibitory peptide harbored in 270/480 kDa ankyrin-G and a super-potent pan-Atg8 in …