Boosting Chemodynamic Therapy by the Synergistic Effect of Co-Catalyze and Photothermal Effect Triggered by the Second Near-Infrared Light

Songtao Zhang; Longhai Jin; Jianhua Liu; Yang Liu; Tianqi Zhang; Ying Zhao; Na Yin; Rui Niu; Xiaoqing Li; Dongzhi Xue; Shuyan Song; Yinghui Wang; Hongjie Zhang

doi:10.1007/s40820-020-00516-z

Boosting Chemodynamic Therapy by the Synergistic Effect of Co-Catalyze and Photothermal Effect Triggered by the Second Near-Infrared Light

Nanomicro Lett. 2020 Sep 2;12(1):180. doi: 10.1007/s40820-020-00516-z.

Authors

Songtao Zhang^{1

2}, Longhai Jin³, Jianhua Liu³, Yang Liu¹, Tianqi Zhang³, Ying Zhao¹, Na Yin¹, Rui Niu¹, Xiaoqing Li¹, Dongzhi Xue¹, Shuyan Song¹, Yinghui Wang⁴, Hongjie Zhang^{5

6

7}

Affiliations

¹ State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS), Changchun, 130022, People's Republic of China.
² University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China.
³ Department of Radiology, The Second Hospital of Jilin University, Changchun, 130041, People's Republic of China.
⁴ State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS), Changchun, 130022, People's Republic of China. yhwang@ciac.ac.cn.
⁵ State Key Laboratory of Rare Earth Resource Utilization, Changchun Institute of Applied Chemistry (CIAC), Chinese Academy of Sciences (CAS), Changchun, 130022, People's Republic of China. hongjie@ciac.ac.cn.
⁶ University of Chinese Academy of Sciences, Beijing, 100049, People's Republic of China. hongjie@ciac.ac.cn.
⁷ Department of Chemistry, Tsinghua University, Beijing, 100084, People's Republic of China. hongjie@ciac.ac.cn.

Abstract

In spite of the tumor microenvironments responsive cancer therapy based on Fenton reaction (i.e., chemodynamic therapy, CDT) has been attracted more attentions in recent years, the limited Fenton reaction efficiency is the important obstacle to further application in clinic. Herein, we synthesized novel FeO/MoS₂ nanocomposites modified by bovine serum albumin (FeO/MoS₂-BSA) with boosted Fenton reaction efficiency by the synergistic effect of co-catalyze and photothermal effect of MoS₂ nanosheets triggered by the second near-infrared (NIR II) light. In the tumor microenvironments, the MoS₂ nanosheets not only can accelerate the conversion of Fe³⁺ ions to Fe²⁺ ions by Mo⁴⁺ ions on their surface to improve Fenton reaction efficiency, but also endow FeO/MoS₂-BSA with good photothermal performances for photothermal-enhanced CDT and photothermal therapy (PTT). Consequently, benefiting from the synergetic-enhanced CDT/PTT, the tumors are eradicated completely in vivo. This work provides innovative synergistic strategy for constructing nanocomposites for highly efficient CDT.

Keywords: Chemodynamic therapy; Co-catalysis; Fenton reaction; NIR II biowindows; Photothermal effect.