Adipocyte-conditioned medium induces resistance of breast cancer cells to lapatinib.
Geneste A, Duong MN, Molina L, Conilh L, Beaumel S, Cleret A, Chettab K, Lachat M, Jordheim LP, Matera EL, Dumontet C.
Geneste A, et al.
BMC Pharmacol Toxicol. 2020 Aug 14;21(1):61. doi: 10.1186/s40360-020-00436-z.
BMC Pharmacol Toxicol. 2020.
PMID: 32795383
Free PMC article.
In addition, resistance was induced with adipocytes derived from murine NIH3T3 or human hMAD cells but not with fibroblasts or preadipocytes. In vivo studies demonstrated that the contact of the tumors with adipose tissue reduced sensitivity to lapatinib. ...
In addition, resistance was induced with adipocytes derived from murine NIH3T3 or human hMAD cells but not with fibroblasts or preadi …