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d-Amino acid substitutions and dimerization increase the biological activity and stability of an IL-15 antagonist peptide.
Rodríguez-Álvarez Y, Cabrales-Rico A, Diago-Abreu D, Correa-Arguelles E, Reyes-Acosta O, Puente-Pérez P, Pichardo-Díaz D, Urquiza-Noa D, Hernández-Santana A, Garay-Pérez HE. Rodríguez-Álvarez Y, et al. Among authors: garay perez he. J Pept Sci. 2021 Mar;27(3):e3293. doi: 10.1002/psc.3293. Epub 2020 Dec 16. J Pept Sci. 2021. PMID: 33331098
Formulation matters! A spectroscopic and molecular dynamics investigation on the peptide CIGB552 as itself and in its therapeutical formulation.
Savioli M, Antonelli L, Bocchinfuso G, Cavalieri F, Cimino R, Gatto E, Placidi E, Fernandez Masso JR, Garay Perez H, Santana H, Guerra-Vallespi M, Venanzi M. Savioli M, et al. Among authors: garay perez h. J Pept Sci. 2022 Jan;28(1):e3356. doi: 10.1002/psc.3356. Epub 2021 Jun 10. J Pept Sci. 2022. PMID: 34114297
Influence of Humoral Response Against GnRH, Generated by Immunization with a Therapeutic Vaccine Candidate on the Evolution of Patients with Castration-Sensitive Prostate Adenocarcinoma.
Campal-Espinosa AC, Junco-Barranco JA, Fuentes-Aguilar F, Calzada-Aguilera L, Rivacoba-Betancourt A, Rodríguez-Bueno RH, Bover-Campal AC, Bover-Fuentes EE, González L, de Quesada L, Alvarez A, Garay-Pérez HE. Campal-Espinosa AC, et al. Among authors: garay perez he. Technol Cancer Res Treat. 2023 Jan-Dec;22:15330338231207318. doi: 10.1177/15330338231207318. Technol Cancer Res Treat. 2023. PMID: 37828833 Free PMC article. Clinical Trial.
In vitro and in vivo characterization of an interleukin-15 antagonist peptide by metabolic stability, 99m Tc-labeling, and biological activity assays.
Rodríguez-Álvarez Y, Cabrales-Rico A, Perera-Pintado A, Prats-Capote A, Garay-Pérez HE, Reyes-Acosta O, Pérez-García E, Chico-Capote A, Santos-Savio A. Rodríguez-Álvarez Y, et al. Among authors: garay perez he. J Pept Sci. 2018 Jun;24(4-5):e3078. doi: 10.1002/psc.3078. Epub 2018 Apr 15. J Pept Sci. 2018. PMID: 29656472