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Bypassing pan-enterovirus host factor PLA2G16.
Baggen J, Liu Y, Lyoo H, van Vliet ALW, Wahedi M, de Bruin JW, Roberts RW, Overduin P, Meijer A, Rossmann MG, Thibaut HJ, van Kuppeveld FJM. Baggen J, et al. Among authors: lyoo h. Nat Commun. 2019 Jul 18;10(1):3171. doi: 10.1038/s41467-019-11256-z. Nat Commun. 2019. PMID: 31320648 Free PMC article.
The trispecific DARPin ensovibep inhibits diverse SARS-CoV-2 variants.
Rothenberger S, Hurdiss DL, Walser M, Malvezzi F, Mayor J, Ryter S, Moreno H, Liechti N, Bosshart A, Iss C, Calabro V, Cornelius A, Hospodarsch T, Neculcea A, Looser T, Schlegel A, Fontaine S, Villemagne D, Paladino M, Schiegg D, Mangold S, Reichen C, Radom F, Kaufmann Y, Schaible D, Schlegel I, Zitt C, Sigrist G, Straumann M, Wolter J, Comby M, Sacarcelik F, Drulyte I, Lyoo H, Wang C, Li W, Du W, Binz HK, Herrup R, Lusvarghi S, Neerukonda SN, Vassell R, Wang W, Adler JM, Eschke K, Nascimento M, Abdelgawad A, Gruber AD, Bushe J, Kershaw O, Knutson CG, Balavenkatraman KK, Ramanathan K, Wyler E, Teixeira Alves LG, Lewis S, Watson R, Haeuptle MA, Zürcher A, Dawson KM, Steiner D, Weiss CD, Amstutz P, van Kuppeveld FJM, Stumpp MT, Bosch BJ, Engler O, Trimpert J. Rothenberger S, et al. Among authors: lyoo h. Nat Biotechnol. 2022 Dec;40(12):1845-1854. doi: 10.1038/s41587-022-01382-3. Epub 2022 Jul 21. Nat Biotechnol. 2022. PMID: 35864170 Free PMC article.
Synthesis, Structure-Activity Relationships, and Antiviral Profiling of 1-Heteroaryl-2-Alkoxyphenyl Analogs as Inhibitors of SARS-CoV-2 Replication.
Bardiot D, Vangeel L, Koukni M, Arzel P, Zwaagstra M, Lyoo H, Wanningen P, Ahmad S, Zhang L, Sun X, Delpal A, Eydoux C, Guillemot JC, Lescrinier E, Klaassen H, Leyssen P, Jochmans D, Castermans K, Hilgenfeld R, Robinson C, Decroly E, Canard B, Snijder EJ, van Hemert MJ, van Kuppeveld F, Chaltin P, Neyts J, De Jonghe S, Marchand A. Bardiot D, et al. Among authors: lyoo h. Molecules. 2022 Feb 4;27(3):1052. doi: 10.3390/molecules27031052. Molecules. 2022. PMID: 35164317 Free PMC article.
Assessment of Kinome-Wide Activity Remodeling upon Picornavirus Infection.
Veth TS, Nouwen LV, Zwaagstra M, Lyoo H, Wierenga KA, Westendorp B, Altelaar MAFM, Berkers C, van Kuppeveld FJM, Heck AJR. Veth TS, et al. Among authors: lyoo h. Mol Cell Proteomics. 2024 May;23(5):100757. doi: 10.1016/j.mcpro.2024.100757. Epub 2024 Mar 30. Mol Cell Proteomics. 2024. PMID: 38556169 Free PMC article.
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